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Grant number: 12/18379-3
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): January 01, 2013
Effective date (End): October 31, 2015
Field of knowledge:Agronomical Sciences - Animal Husbandry - Animal Production
Principal Investigator:Helder Louvandini
Grantee:Érika Breda Canova
Host Institution: Centro de Energia Nuclear na Agricultura (CENA). Universidade de São Paulo (USP). Piracicaba , SP, Brazil


The improvement of the Brazilian sheep productivity has been limited by the gastrointestinal nematodes. The problem with the pathogenic parasites, not only the infection, but also the high resistant against the main anthelmintics drugs on the market. In this sense, it is necessary to use new sustainable alternatives for its control. Tanniferous plants have been used as one of these alternatives for controlling the ruminant's parasite due to their secondary metabolites content that classified chemically as tannins. Depending on the type, activity and concentrations, Tannins were used to improve animal production and are promising compounds to manipulate the gastrointestinal nematodes of sheep. Thus the objective of this work is to study in vitro effect of different 15 acetonic extract from leguminous plants on esxheathment of the L3 cuticle of Haemonchus contortus, and motility test of the free-living nematode Caenorhabditis elegans.. Subsequently, two plants extracts with the most promising in vitro results will be selected for the in vivo evaluation using 24 animals artificially infected with Haemonchus contortus. The animals will be divided into three groups: Group1 receiving the best plant test in vitro. Group2 getting the second best plant and Group3 control. The experiment will take 53 days, during this period the animals will be evaluated by counting parasite eggs in feces (OPG), hematocrit, body weight and biochemical profiles of liver and kidney. Hatchability tests will be carried out with the feces of animals under treatment to verify the viability of the eggs. At the end, the animals will be slaughtered and abomasum will be separated to perform the total count of parasites.

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
CANOVA, Érika Breda. Tanniferous plants (leguminous) efficiency for controlling gastrointestinal parasitism of sheep. 2016. Doctoral Thesis - Universidade de São Paulo (USP). Centro de Energia Nuclear na Agricultura (CENA/STB) Piracicaba.

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