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Cognitive profile in tobacco smokers: relationship with respiratory parameters and oxidative stress

Grant number: 12/20664-8
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): February 01, 2013
Effective date (End): August 09, 2015
Field of knowledge:Humanities - Psychology - Physiological Psychology
Principal Investigator:Sabine Pompéia
Grantee:Raquel de Luna Antonio
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil


Smoking tobacco affects the central nervous system in several ways including decreased brain oxygen supply and alterated metabolism of gasotransmissors such as nitric oxide and carbon monoxide. However, the relations of these effects with smoking-induced cognitive impairment are largely unknown and will be explored in this project by two experiments: 1) a cross-sectional study with 80 subjects in order to characterize the cognitive impairment of smokers and determine how these deficits are related to respiratory parameters/oxidative stress in young adults with high and low cognitive stimulation (schooling / socioeconomic status), since the latter affects both smoking habits and cognition; and 2) evaluate the effects of daily practice of breathing exercises [kapalabhati technique,which activates the sympathetic system; nadi shodhana technique, which activates the parasympathetic system; or performing sudoko/crossword, anactive control for the attentional aspect of breathing practices] for 8 weeks on cognition, mood and respiratory parameters/oxidative stress in smokers, since such exercises are capable of positively affecting these functions ( 20 subjects per group). This study has the potential to determine factors that predispose smokers to develop cognitive problems and proposes a possible harm reduction technique in this population.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ANTONIO, RAQUEL DE LUNA; POMPEIA, SABINE. A fractionated analysis of hot and cool self-regulation in cigarette smokers from different socioeconomic backgrounds. PLoS One, v. 14, n. 8 AUG 20 2019. Web of Science Citations: 0.
PEREIRA DA SILVA, VICTOR HUGO; DE LUNA ANTONIO, RAQUEL; POMPEIA, SABINE; RIBEIRO, DANIEL ARAKI. Cytogenetic Biomonitoring in Buccal Mucosa Cells from Young Smokers. ACTA CYTOLOGICA, v. 59, n. 6, p. 474-478, 2015. Web of Science Citations: 6.

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