| Grant number: | 12/23537-7 |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| Start date: | February 01, 2013 |
| End date: | December 31, 2013 |
| Field of knowledge: | Biological Sciences - Immunology - Cellular Immunology |
| Principal Investigator: | Luciane Alarcão Dias-Melicio |
| Grantee: | Juliana Carvalho de Quaglia e Silva |
| Host Institution: | Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil |
Abstract Studies have shown that cells of innate immunity, such as neutrophils and monocytes, mediate the initial recognition of microorganisms through the expression of receptors known as Pattern Recognition Receptors (PRRs). The dectin-1 is an example of PRR that recognize ²-glucan, a major component of fungal cell wall. It has been shown that in fungal infections, the fungus binding with dectin-1 induces cytokine production and other responses, which may lead to a variety of protective cellular responses against the fungi. Aiming a better understanding of the cell activation process during the confrontation fungus-phagocyte, will be evaluated the dectin-1 expression by human monocytes and neutrophils, activated with different cytokines and challenged in vitro with different strains of P. brasiliensis, and will also be evaluated the participation of this receptor in fungicidal activity and production of hydrogen peroxide (H2O2) in these same cultures. | |
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