Synthesis, structural characterization and biological studies of silver(I) complexes with Schiff bases derivated from Nimesulide

• Grant number: 12/21955-6
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: February 01, 2013
• End date: July 31, 2013
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Principal Investigator: Pedro Paulo Corbi
• Grantee: Julia Helena Bormio Nunes
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Metal complexes with pharmacological applications have been used in medicine for centuries. Platinum complexes, for example, are used in the treatment of cancer since the 70's of last century, vanadium complexes are currently used to treat diabetes while complexes of gold and silver have been used in the treatment of rheumatoid arthritis and in the treatment of bacterial infections, respectively. For this project, we propose the synthesis of Ag(I) complexes with Schiff bases derived from the anti-inflammatory drug Nimesulide. Schiff bases are biologically important, occurring in the metabollism as transamination intermediates. The compounds obtained will be characterized by several techniques, with emphasis on analysis by nuclear magnetic resonance 1H, 13C and 15N, infrared spectroscopy and mass spectrometry. The compounds will be evaluated initially regarding its antibacterial and antitumor activities, and the results obtained will be compared with commercially available drugs. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

NUNES, JULIA H. B.; NAKAHATA, DOUGLAS H.; LUSTRI, WILTON R.; CORBI, PEDRO P.; DE PAIVA, RAPHAEL E. F.. The nitro-reduced metabolite of nimesulide: Crystal structure, spectroscopic characterization, ESI-QTOF mass spectrometric analysis and antibacterial evaluation. Journal of Molecular Structure, v. 1157, p. 469-475, APR 5 2018. (15/09833-0, 12/21955-6, 15/20882-3)