Analysis of dead space contribution to blood gas abnormalities and breathing patterns in COPD patients

• Grant number: 12/05190-0
• Support Opportunities: Scholarships abroad - Research
• Start date: January 01, 2014
• End date: December 31, 2014
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Paolo José Cesare Biselli
• Grantee: Paolo José Cesare Biselli
• Host Investigator: Alan Richard Schwartz
• Host Institution: Hospital Universitário (HU). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Institution abroad: Johns Hopkins University (JHU), United States

Abstract

In Brazil, COPD is the 4th cause of mortality in men and the 5th in women. During sleep, COPD patients experience a reduction in the respiratory drive, producing decreases in total ventilation and increases in dead space ventilation. Resulting decreases in alveolar ventilation lead to increasing hypercapnia and changes in breathing pattern. In previous studies, we have found evidence that nasal insufflation can decrease dead space ventilation and reduce nocturnal hypercapnia in COPD. Our overall hypothesis is that ventilatory disturbances during sleep in COPD are primarily due to increases in dead space ventilation and can be reversed with nasal insufflation. Specifically, our aims are: Specific Aim 1: To examine the impact of dead space volume on ventilation and gas exchange during sleep. We hypothesize that increasing degrees of space volumes produce greater sleep associated hypercapnia and impairments in breathing mechanics. Specific Aim 2: To examine the effect of altering dead space volume on ventilation and gas exchange during sleep. We hypothesize that lowering dead space ventilation will improve efficiency of breathing and gas exchange in COPD.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BISELLI, PAOLO; FRICKE, KATHRIN; GROTE, LUDGER; BRAUN, ANDREW T.; KIRKNESS, JASON; SMITH, PHILIP; SCHWARTZ, ALAN; SCHNEIDER, HARTMUT. Reductions in dead space ventilation with nasal high flow depend on physiological dead space volume: metabolic hood measurements during sleep in patients with COPD and controls. European Respiratory Journal, v. 51, n. 5, MAY 1 2018. (12/05190-0)

BISELLI, PAOLO J. C.; KIRKNESS, JASON P.; GROTE, LUDGER; FRICKE, KATHRIN; SCHWARTZ, ALAN R.; SMITH, PHILIP; SCHNEIDER, HARTMUT. Nasal high-flow therapy reduces work of breathing compared with oxygen during sleep in COPD and smoking controls: a prospective observational study. Journal of Applied Physiology, v. 122, n. 1, p. 82-88, JAN 2017. (12/05190-0)