Salivation in chronic intermittent hypoxia rats

• Grant number: 13/02027-3
• Support Opportunities: Scholarships abroad - Research Internship - Scientific Initiation
• Start date: June 29, 2013
• End date: July 28, 2013
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Patricia Maria de Paula
• Grantee: Lucas Arrais de Campos
• Supervisor: Steve Wayne Mifflin
• Host Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• Institution abroad: UNT Health Science Center, United States
• Associated to the scholarship: 10/15021-5 - Involvement of purinergic receptors in the basal and salivation induced by pilocarpine in rats., BP.IC

Abstract

The salivation is under control of autonomic nervous system. Studies have showen that animals submitted to chronic hypoxia and application of anoxic or hypoxic perfusate in isolated salivary glands reduced salivary flow. However, there are no evidences that show how is the salivation in animals submitted to chronic intermittent hypoxia (CIH). Chronic exposure to intermittent hypoxia is a widely used animal model of the arterial hypoxemia that occurs during sleep apnea. CIH in animals has been shown to result in an increased blood pressure as seen in human sleep apnea patients and this hypertension is dependent upon the sympathetic nervous system, angiotensin and the renal sympathetic nerves. Thus, the goal of the present proposal is to investigate the basal salivation and salivation induced by pilocarpine (muscarinic cholinergic agonist) administered intraperitoneally (ip) in normoxic and CIH rats. (AU)