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Salivation in chronic intermittent hypoxia rats

Grant number: 13/02027-3
Support type:Scholarships abroad - Research Internship - Scientific Initiation
Effective date (Start): June 29, 2013
Effective date (End): July 28, 2013
Field of knowledge:Biological Sciences - Physiology
Principal Investigator:Patricia Maria de Paula
Grantee:Lucas Arrais de Campos
Supervisor abroad: Steve Wayne Mifflin
Home Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Local de pesquisa : UNT Health Science Center, United States  
Associated to the scholarship:10/15021-5 - Involvement of purinergic receptors in the basal and salivation induced by pilocarpine in rats, BP.IC


The salivation is under control of autonomic nervous system. Studies have showen that animals submitted to chronic hypoxia and application of anoxic or hypoxic perfusate in isolated salivary glands reduced salivary flow. However, there are no evidences that show how is the salivation in animals submitted to chronic intermittent hypoxia (CIH). Chronic exposure to intermittent hypoxia is a widely used animal model of the arterial hypoxemia that occurs during sleep apnea. CIH in animals has been shown to result in an increased blood pressure as seen in human sleep apnea patients and this hypertension is dependent upon the sympathetic nervous system, angiotensin and the renal sympathetic nerves. Thus, the goal of the present proposal is to investigate the basal salivation and salivation induced by pilocarpine (muscarinic cholinergic agonist) administered intraperitoneally (ip) in normoxic and CIH rats. (AU)

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