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Regulation of mitochondrial function and metabolism of glucose and fatty acids by factor of hypoxia inducible (HIF-1a) muscle cells in insulin resistance

Grant number: 12/17416-2
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): April 01, 2013
Effective date (End): August 31, 2016
Field of knowledge:Health Sciences - Physical Education
Principal Investigator:Leonardo dos Reis Silveira
Grantee:Michel Barbosa de Araújo
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:13/07607-8 - OCRC - Obesity and Comorbidities Research Center, AP.CEPID
Associated scholarship(s):15/02278-1 - Regulation of mitochondrial function by hypoxia inducible factor (HIF-1) in insulin resistant muscle cells, BE.EP.PD

Abstract

The insulin resistance in skeletal muscle is a characteristic in diabetics people. Although its mechanism is not totaly known, there is correlation between insulin resistance and intracellular lipid content. However, there is consensus that there is a strong correlation between insulin resistance, physical inactivity and high intracellular lipid content. Our proposal is to evaluate the effect of gene expression of HIF1± in mitochondrial biogenesis in uptake and metabolism of glucose, fatty acid, reactive species production and proteolysis. In order to have a positive control, the effect of its inhibition on the variables mentioned in cells resistant to insulin will also be assess . Our hypothesis is that HIF1± may protect against insulin resistance in the muscle improving mitochondrial function. Confirming our hypothesis, the HIF1±, or even pharmacological compounds that are capable of inhibiting expression of this gene may constitute itself important therapeutic targets against of development insulin resistance in muscle tissue.