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Role of BIM in the immune response to Trypanosoma cruzi during the experimental infection and as a result of vaccination with plasmid DNA and recombinant adenovirus

Grant number: 12/24737-0
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): August 01, 2013
Effective date (End): July 31, 2015
Field of knowledge:Biological Sciences - Immunology - Applied Immunology
Principal Investigator:João Gustavo Pessini Amarante Mendes
Grantee:Marcela Hernández Torres
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Currently, vaccines based on recombinant viruses represent one of the most important areas for the study of new vehicles that are effective in the delivery of antigen. The frequency and quality of memory T lymphocytes that are generated during the immune response to a particular pathogen are absolutely essential for the establishment of a protection state against the specific pathogen.The homeostasis of T lymphocyte compartment is established through two processes of cell death that install due to the initial antigenic stimulus. These processes, called ACAD and AICD are controlled by members of the family BCL-2 or by death receptors, among which stands out the FAS/CD95. Recently, downregulation of FAS has been implicated in the quality of the protection conferred by vaccination with recombinant adenovirus in a murine model of Chagas Disease. In this work, we will investigate the role of BIM, a pro-apoptotic protein that controls the process ACAD, in immunity against infection by T. cruzi conferred by vaccination with plasmid DNA and recombinant adenovirus.

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
TORRES, Marcela Hernández. Role of Bim protein in the immune response to Trypanosoma cruziduring experimental infection.. 2015. Master's Dissertation - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.

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