Analysis of the patterns of antibiotic sensitivity in pioneer strains of streptococci from the oral cavity

• Grant number: 13/06820-0
• Support type: Scholarships abroad - Research Internship - Scientific Initiation
• Effective date (Start): July 01, 2013
• Effective date (End): July 31, 2013
• Field of knowledge: Health Sciences - Dentistry
• Principal researcher: Renata de Oliveira Mattos Graner
• Grantee: Thaís Harder de Palma
• Supervisor abroad: Margaret J. Duncan
• Home Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil
• Research place: Forsyth Institute, United States
• Associated to the scholarship: 11/09761-9 - Analysis of patterns of antibiotic sensitivity in pioneer strains of Streptococcus of the human oral cavity., BP.IC

Abstract

This project aims to complement the Scientific Initiation Research Project entitled "Analysis of the patterns of antibiotic sensitivity in pioneer strains of Streptococci from the oral cavity". In this project, we identified in the oral cavity of 2 to 16-month-old children, a high prevalence of strains of Streptococcus salivarius, which were resistant to several classes of antibiotics (beta-lactams, tetracyclines, macrolides, and aminoglycosides). Among the 21 children studied, a total of 79 S. salivarius strains were resistant to one or more antibiotics. Among these, 26 were resistant to two or more classes of antibiotics indicating a multidrug resistance phenotype. The objective of this BEPE project is to identify genes involved in the phenotype of resistance to multiple antibiotics in the strains of Streptococcus salivarius isolated from the oral cavity of children who were 2-16 months of age. This internship will be performed at The Forsyth Institute under the supervision of Dr. Margaret J. Duncan, Department of Microbiology, The Forsyth Institute, Cambridge, MA, USA in July 2013. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PALMA, THAIS H.; HARTH-CHU, ERIKA N.; SCOTT, JODIE; STIPP, RAFAEL N.; BOISVERT, HEIKE; SALOMAO, MARIANA F.; THEOBALDO, JESSICA D.; POSSOBON, ROSANA F.; NASCIMENTO, LEANDRO C.; MCCAFFERTY, JONATHAN W.; FALLER, LINA; DUNCAN, MARGARET J.; MATTOS-GRANER, RENATA O. Oral cavities of healthy infants harbour high proportions of Streptococcus salivarius strains with phenotypic and genotypic resistance to multiple classes of antibiotics. Journal of Medical Microbiology, v. 65, n. 12, p. 1456-1464, DEC 2016. Web of Science Citations: 4.