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Osseointegration of titanium implants covered by nanotubes and installed without primary stability: influence of association fibrin adhesive/tranexamic acid

Grant number: 12/24545-3
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): May 01, 2013
Effective date (End): November 30, 2014
Field of knowledge:Interdisciplinary Subjects
Principal researcher:Maria Cristina Rosifini Alves Rezende
Grantee:Bruna Cabrera Capalbo
Home Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil


When implants are installed immediately after tooth extraction may occur anchoring primary and decreased delay and/or impairment of the osseointegration process. This occurs because of the large interface between the surrounding walls of the socket and the surface of the implant. The purpose of this study is to evaluate Histomorphometric analysis in rat bone healing around implants with nanotubular oxide surface associated with fibrin adhesive/ tranexamic acid. Will be made 80 implants of titanium ASTM F67 (Grade 4), with dimensions of 2.1 x 2.8mm, CNC machined around STAR ® model SR-20RII, with a power of 2.2 kW. The implants will be identified, individually packaged, sterilized by gamma radiation (25 kGy), and divided into GI (machined), GII (machined/fibrin adhesive), GIII (machined/tranexamic acid), GIV (machined/ fibrin adhesive /tranexamic acid), GV (nanotubular oxide surface), GVI (nanotubular oxide surface/fibrin adhesive), GVII (nanotubular oxide surface / tranexamic acid) and GVIII (nanotubular oxide surface/fibrin adhesive/ tranexamic acid). Following are implanted in femurs of 80 male rats (250 grams), which will be anesthetized (Xylazine / Ketamine) and shaved on its hind legs straight. After incision, divulsion, access to the bone bed, and punching over milling (twist drill with 2.5 mm in diameter) under irrigation with saline, the surgical beds will be filled with the material to each group and the implants installed. Following is sutured (4.0 wire). The animals will be sacrificed at 60 days postoperatively. The pieces will be processed in MMA (Stevenel's blue / Alizarin red S).Uniforms: dental implants, osseointegration, nanotubes, fibrin tissue adhesive, tranexamic acid.(AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ALVES-REZENDE, MARIA C. R.; CAPALBO, LETICIA C.; DE OLIVEIRA LIMIRIO, JOAO P. J.; CAPALBO, BRUNA C.; LIMIRIO, PEDRO H. J. O.; ROSA, JORGE L. The role of TiO2 nanotube surface on osseointegration of titanium implants: Biomechanical and histological study in rats. MICROSCOPY RESEARCH AND TECHNIQUE, v. 83, n. 7 MAR 2020. Web of Science Citations: 0.

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