Surface modification of the Ti-15Mo alloy for drug delivery

• Grant number: 13/00317-4
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: June 01, 2013
• End date: June 30, 2017
• Field of knowledge: Interdisciplinary Subjects
• Principal Investigator: Ana Paula Rosifini Alves
• Grantee: André Luiz Reis Rangel
• Host Institution: Faculdade de Engenharia (FEG). Universidade Estadual Paulista (UNESP). Campus de Guaratinguetá. Guaratinguetá , SP, Brazil
• Associated scholarship(s): 15/26273-9 - Surface modification of Ti-15Mo alloys to drugs release, BE.EP.DD

Abstract

In the present study, the drug delivery in surface of the Ti-15Mo alloy will be evaluated after nanotubes growth. Ingots will be obtained from titanium and tantalum by using an arc-melting furnace. They will be submitted to heat treatment and cold worked by swaging. After nanotubes growth in the surface of the samples, drug will be incorporated and surface will be coated using two techniques: plasma deposition and dip coating. Scanning electron Microscopy (SEM), contact angle and UV spectroscopy will be used for surface analysis. In vitro studies, such as, cell growth and biofilms will be used to evaluate drug incorporation. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

RANGEL, ANDRE L. R.; FALENTIN-DAUDRE, CELINE; ALVES DA SILVA PIMENTEL, BRUNA NATALIA; VERGANI, CARLOS EDUARDO; MIGONNEY, VERONIQUE; ALVES CLARO, ANA P. R.. Nanostructured titanium alloy surfaces for enhanced osteoblast response: A combination of morphology and chemistry. SURFACE & COATINGS TECHNOLOGY, v. 383, FEB 15 2020. (15/25124-0, 15/13834-2, 13/00317-4, 15/26273-9)