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Neuroprotective effects of Edaravone in experimental hydrocephalus induced in wistar rats

Grant number: 13/04130-6
Support type:Scholarships in Brazil - Master
Effective date (Start): June 01, 2013
Effective date (End): January 31, 2015
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Helio Rubens Machado
Grantee:Camila Araujo Bernardino Garcia
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


Hydrocephalus is usually defined as a defect in the flow of cerebrospinal fluid or absorption resulting in a bulge in the ventricular system, leading to increased intracranial pressure. The treatment of hydrocephalus is usually used surgery with cerebrospinal fluid shunts. However, not all patients with hydrocephalus may be undergoing surgical treatment immediately after diagnosis, either by presenting unfavorable conditions or even submit initial ventricular dilatation. Although lesions of hydrocephalus be multifactorial, it is known that oxidative stress is one of the mechanisms involved. The edaravone is a drug that acts on oxidative stress and was recently introduced in the treatment of cerebral ischemia, but has not been tested in hydrocephalus. This study will evaluate the neuroprotective effects of Edaravone in response experimental hydrocephalus in young male Wistar rats 7 days of life will receive an injection of kaolin and 15% in the cisterna magna. These animals will be divided into three groups: control (n = 5), untreated hydrocephalus (n = 10), hydrocephalus treated with Edaravone (30mg/kg) (n = 20). The treatment groups will receive the drug every day from the first day after induction. Will be conducted behavioral tests Open Field and T-maze, studies of magnetic resonance, biochemical, histological and immunohistochemistry. It is expected that the results of this work, offer another alternative treatment in patients with hydrocephalus.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DA SILVA, STEPHANYA COVAS; FERES, OMAR; BEGGIORA, PAMELLA DA SILVA; MACHADO, HELIO RUBENS; MENEZES-REIS, RAFAEL; ARAUJO, JOAO EDUARDO; BRANDAO, RICARDO ANDRADE; LOPES, LUIZA DA SILVA. Hyperbaric oxygen therapy reduces astrogliosis and helps to recovery brain damage in hydrocephalic young rats. CHILD'S NERVOUS SYSTEM, v. 34, n. 6, p. 1125-1134, JUN 2018. Web of Science Citations: 1.
BERNARDINO GARCIA, CAMILA ARAUJO; ROCHA CATALAO, CARLOS HENRIQUE; MACHADO, HELIO RUBENS; MATIAS JUNIOR, IVAIR; ROMEIRO, THAIS HELENA; PEIXOTO-SANTOS, JOSE EDUARDO; SANTOS, MARCELO VOLPON; LOPES, LUIZA DA SILVA. Edaravone reduces astrogliosis and apoptosis in young rats with kaolin-induced hydrocephalus. CHILD'S NERVOUS SYSTEM, v. 33, n. 3, p. 419-428, MAR 2017. Web of Science Citations: 3.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
GARCIA, Camila Araujo Bernardino. Neuroprotective effects of edaravone in experimentally induced hydrocephalus in Wistar rats. 2015. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto Ribeirão Preto.

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