Influence of functional and strength training on neuromuscular adaptations, functionality and quality of life in elderly with Parkinson's Disease

• Grant number: 13/04970-4
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: June 01, 2013
• End date: June 30, 2015
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Carlos Ugrinowitsch
• Grantee: Carla da Silva Batista
• Host Institution: Escola de Educação Física e Esporte (EEFE). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Decline in the neuromuscular function inherent to the aging process aggravate motor changes alterations produced by the Parkinson's disease (PD), such as bradykinesia, postural instability and rigidity. These motor symptoms interfere drastically when performing activities of daily living (i.e., functionality) of individuals with PD and cause frequent falls. Associated with these symptoms, a decrease in the ability to force production observed in these individuals also impairs the functionality and therefore increases the risk of falls and worsening the quality of life of this population. Additionally, such decrease in the ability to produce force may be a result of changes in some spinal inhibitory mechanisms due to abnormal efferent drive from the basal ganglia to the spinal cord of patients with PD. Thus, interventions that can slow or reverse this situation are extremely important for maintaining or improving the quality of life of this population. Previous studies have shown that strength training (ST) seems to be able to promote brain neuroplasticity and improve some functional deficits in individuals with PD by increasing muscle strength. However, the effects of this intervention on the ability to force production in spinal inhibitory mechanisms in motor symptoms, decreasing the risk of falling and quality of life of individuals with PD to date are unknown. Moreover, a training model that also increases muscle strength to enhance the functionality of individuals with PD, however, that requires a great demand proprioceptive and motor control during execution, may be more effective than the ST to improve all these variables described above. Accordingly, the functional training or ST under conditions of instability (STI) appears to be very promising since individuals with PD held power drills having a main support base (i.e., responsible for sustaining most of the body weight) of unstable conditions. However, analogously to ST the adjustments produced by STI in this population also are unknown. Thus, the objective of this study is to analyze and compare the effect of 12 weeks of ST and STI in the neuromuscular adaptations, functionality, motor symptoms, the risk of falling and quality of life of individuals in stage 2 and 3 of the PD and verify if individuals with PD who carry out the intervention of ST and STI will approach the situation of the healthy control after intervention both in functionality and in neuromuscular adaptations. (AU)

Scientific publications

(9)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

RAMOS, GUILHERME SILVA; SILVA-BATISTA, CARLA; PALMA, BARTIRA PEREIRA; UGRINOWITSCH, CARLOS; DA CUNHA, TELMA FATIMA. Risk of falls using the Biodex Balance System in non-faller patients with Parkinson Disease. SOMATOSENSORY AND MOTOR RESEARCH, DEC 2021. (16/13115-9, 13/04970-4)

SILVA-BATISTA, CARLA; DE BRITO, LEANDRO C.; CORCOS, DANIEL M.; ROSCHEL, HAMILTON; DE MELLO, MARCO T.; PIEMONTE, MARIA E. P.; TRICOLI, VALMOR; UGRINOWITSCH, CARLOS. RESISTANCE TRAINING IMPROVES SLEEP QUALITY IN SUBJECTS WITH MODERATE PARKINSON'S DISEASE. JOURNAL OF STRENGTH AND CONDITIONING RESEARCH, v. 31, n. 8, p. 2270-2277, AUG 2017. (12/03056-4, 13/04970-4)

SILVA-BATISTA, CARLA; TAVARES MATTOS, EUGENIA CASELLA; CORCOS, DANIEL M.; WILSON, JESSICA M.; HECKMAN, CHARLES J.; KANEGUSUKU, HELCIO; PIMENTEL PIEMONTE, MARIA ELISA; DE MELLO, MARCO TULIO; FORJAZ, CLAUDIA; ROSCHEL, HAMILTON; et al. Resistance training with instability is more effective than resistance training in improving spinal inhibitory mechanisms in Parkinson's disease. Journal of Applied Physiology, v. 122, n. 1, p. 1-10, JAN 2017. (12/03056-4, 13/04970-4)

DE OLIVEIRA LIRA, JUMES LEOPOLDINO; UGRINOWITSCH, CARLOS; FECCHIO, RAFAEL; COELHO, DANIEL BOARI; MOREIRA-NETO, ACACIO; GERMANO, RENAN; DE LIMA MILIATTO, ANGELO CORREA; DOS SANTOS VIEIRA YANO, BIANCA CRISTINA; SILVA-BATISTA, CARLA. Minimal Detectable Change for Balance Using the Biodex Balance System in Patients with Parkinson Disease. PM&R, v. 12, n. 3, p. 281-287, MAR 2020. (13/04970-4, 16/13115-9)

SILVA-BATISTA, CARLA; CORCOS, DANIEL M.; KANEGUSUKU, HELCIO; PIMENTEL PIEMONTE, MARIA ELISA; BUCKEN GOBBI, LILIAN TERESA; DE LIMA-PARDINI, ANDREA C.; DE MELLO, MARCO TULIO; FORJAZ, CLAUDIA L. M.; UGRINOWITSCH, CARLOS. Balance and fear of falling in subjects with Parkinson's disease is improved after exercises with motor complexity. GAIT & POSTURE, v. 61, p. 90-97, MAR 2018. (12/03056-4, 13/04970-4)

SILVA-BATISTA, CARLA; CORCOS, DANIEL MONTIE; BARROSO, RENATO; DAVID, FABIAN J.; KANEGUSUKU, HELCIO; FORJAZ, CLAUDIA; DE MELLO, MARCO TULIO; ROSCHEL, HAMILTON; TRICOLI, VALMOR; UGRINOWITSCH, CARLOS. Instability Resistance Training Improves Neuromuscular Outcome in Parkinson's Disease. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 49, n. 4, p. 652-660, APR 2017. (12/03056-4, 13/04970-4)

SILVA-BATISTA, CARLA; CORCOS, DANIEL M.; ROSCHEL, HAMILTON; KANEGUSUKU, HELCIO; BUCKEN GOBBI, LILIAN TERESA; PIMENTEL PIEMONTE, MARIA ELISA; TAVARES MATTOS, EUGENIA CASELLA; DE MELLO, MARCO TULIO; FORJAZ, CLAUDIA L. M.; TRICOLI, VALMOR; et al. Resistance Training with Instability for Patients with Parkinson's Disease. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 48, n. 9, p. 1678-1687, SEP 2016. (12/03056-4, 13/04970-4)

SILVA-BATISTA, CARLA; KANEGUSUKU, HELCIO; ROSCHEL, HAMILTON; SOUZA, EDUARDO O.; CUNHA, TELMA F.; LAURENTINO, GILBERTO C.; MANOEL, JR., N.; DE MELLO, MARCO T.; PIEMONTE, MARIA E. P.; BRUM, PATRICIA C.; et al. Resistance Training with Instability in Multiple System Atrophy: A Case Report. JOURNAL OF SPORTS SCIENCE AND MEDICINE, v. 13, n. 3, p. 597-603, SEP 2014. (12/03056-4, 13/04970-4)

DE ALMEIDA, FILIPE OLIVEIRA; UGRINOWITSCH, CARLOS; BRITO, LEANDRO C.; MILLIATO, ANGELO; MARQUESINI, RAQUEL; MOREIRA-NETO, ACACIO; BARBOSA, EGBERTO REIS; HORAK, FAY B.; MANCINI, MARTINA; SILVA-BATISTA, CARLA. Poor sleep quality is associated with cognitive, mobility, and anxiety disability that underlie freezing of gait in Parkinson's disease. GAIT & POSTURE, v. 85, p. 7-pg., 2021-02-09. (13/04970-4, 16/13115-9, 18/16909-1)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

BATISTA, Carla da Silva. Effects of strength training and strength training with instability on the symptoms, functionality, neuromuscular adaptations, and the quality of life of patients with parkinson\'s disease: a randomized controlled trial. 2016. Doctoral Thesis - Universidade de São Paulo (USP). Escola de Educação Física e Esportes (EEFE/BT) São Paulo.