Morphological and functional research of neurons derived from induced pluripotent stem cells from autistic spectrum disorder patients

• Grant number: 13/08844-3
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• Start date: November 01, 2013
• End date: October 31, 2014
• Field of knowledge: Biological Sciences - Biology
• Principal Investigator: Patricia Cristina Baleeiro Beltrão Braga
• Grantee: Fabiele Baldino Russo
• Supervisor: Alysson Renato Muotri
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Institution abroad: University of California, San Diego (UC San Diego), United States
• Associated to the scholarship: 11/20683-0 - Generation of induced pluripotent cells of patients with autistic disorder, BP.DR

Abstract

The idiopathic autism is a disorder classified within the Autism Spectrum Disorder (ASD) affects the development psychoneurological and the ability to communicate, understand and speak thus affecting your social life. It is a disease even without genetic causes as well elucidated and pediatric of major concern, with increasing incidence. Currently, it is estimated that 1% of all school-age children in the United States have ASD, and its even higher incidence in boys, the order of one for every 55. In Brazil there are still no data on the incidence, only isolated publications.In this project we intend to study morphologically and functionally neurons derived from induced pluripotent cells (iPSC) from patients with idiopathic autism, featuring extensively these cells and comparing them with neurons of patients without autism. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ROSA-FERNANDES, LIVIA; CUGOLA, FERNANDA RODRIGUES; RUSSO, FABIELE BALDINO; KAWAHARA, REBECA; DE MELO FREIRE, CAIO CESAR; CORREA LEITE, PAULO EMLIO; BASSI STERN, ANA CAROLINA; ANGELI, CLAUDIA BLANES; LEAL DE OLIVEIRA, DANIELLE BRUNA; MELO, STELLA REZENDE; et al. Zika Virus Impairs Neurogenesis and Synaptogenesis Pathways in Human Neural Stem Cells and Neurons. FRONTIERS IN CELLULAR NEUROSCIENCE, v. 13, MAR 15 2019. (16/02978-6, 14/06863-3, 13/08844-3, 18/16748-8, 11/20683-0, 15/02866-0)