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Luminescent metallic complexes with phenolic acids coordinated selective targets to mitochondria and antioxidant activity mapping in real time by fluorescent techniques

Grant number: 13/05536-6
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): June 01, 2013
Effective date (End): May 31, 2017
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
Principal Investigator:Rose Maria Carlos
Grantee:Eldevan dos Santos Silva
Home Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
Associated scholarship(s):15/23146-6 - Luminescent quenching of riboflavin excited state and protective effects on carotenoids radical by magnesium complexes containing hesperidin and poliphenols, BE.EP.DR

Abstract

Mitochondrias are organelles essentials for the life and death of the cell, participating of the cellular energy metabolism as well as in the control of programmed cell death. In this project we chose to develop mitochondria-targeted antioxidants because the respiratory chain is the major source of reactive oxygen species in vivo, and mitochondrial oxidative damage is the cause or lead to worsening of many chronic diseases. For this reason, we are preparing metal complexes of the type cis-[Mg (L) 2 (phenX)], where phenX = 1,10-phenanthroline derivatized with lipophilic organic dyes (resourufin and rhodamine) and L are phenolic acids: ferulic acid, isovanilic and gallic acid. The phenolic acids are natural antioxidants to protect mitochondria from oxidative damage in vivo. Magnesium is an essential element in biologic medium particularly in ATP synthesis by mitochondria. The phenanthroline-derivatized dyes to enhance uptake because of their lipophilic character and luminescent properties that favors mitochondria selectivity. The therapeutic potential of these complexes and free phenolic acids will be assessed in relation to bioavaiabilitiy (solubility, lipophilicity), antioxidant activity and toxicity in vitro and in vivo for comparison purposes and investigates the neuroprotective effects of the antioxidant compounds proposed in an animal model of Parkinson's disease. We hope that this research will open new possibilities for the development of more selective compounds and therefore less toxic antioxidants to be used as therapeutic agent and diagnostic tools allowing real-time physiological data collection. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MARCHI, RAFAEL C.; SILVA, ELDEVAN S.; SANTOS, JOSENILTON J.; GUILOSKI, IZONETE C.; DE JESUS, HUGO CESAR R.; DE AGUIAR, INARA; KOCK, FLAVIO V. C.; VENANCIO, TIAGO; DA SILVA, MARIA FATIMA G. F.; FERNANDES, JOAO BATISTA; VITAL, MARIA A. B. F.; SOUZA, LEONARDO CASTRO; SILVA DE ASSIS, HELENA C.; SKIBSTED, LEIF H.; CARLOS, ROSE M. Synthesis, Characterization, and Low-Toxicity Study of a Magnesium(II) Complex Containing an Isovanillate Group. ACS OMEGA, v. 5, n. 7, p. 3504-3512, FEB 25 2020. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.

Filed patent(s) as a result of this research project

Solicitação em análise e dentro do prazo legal de sigilo previsto na legislação BR1020180687085 - Universidade Estadual Paulista (UNESP) ; Universidade Federal de São Carlos (UFSCAR) ; Universidade Federal do Paraná (UFPR) . Solicitação em análise e dentro do prazo legal de sigilo previsto na legislação - September 2018, 14