Gene-environment interactions in Schizophrenia and other psychotic disorders

• Grant number: 13/11167-3
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: August 01, 2013
• End date: July 31, 2016
• Field of knowledge: Health Sciences - Medicine - Psychiatry
• Principal Investigator: Cristina Marta Del-Ben
• Grantee: Rosana Shuhama
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated research grant: 12/05178-0 - Schizophrenia and other psychotic disorders: social and biological determinants, AP.TEM

Abstract

Este projeto temático faz parte de estudo multicêntrico, the European Network of National Networks Studying Schizophrenia Gene-Environment Interactions (EU-GEI; http://www.eu-gei.eu/), um consórcio internacional que tem como objetivo investigar a etiologia, mecanismos e prognóstico da esquizofrenia e outros transtornos psicóticos (EOP). Pretende-se estimar a incidência de EOP na região de Ribeirão Preto-SP, Brasil, e investigar possíveis interações entre fatores sociais e biológicos na ocorrência de transtornos mentais. Especificamente para a posição de pós-doutor, o pesquisador conduzirá o subprojeto Interações genético-ambientais na Esquizofrenia e Outros Transtornos Psicóticos, destinado a investigar: a) possíveis variações na incidência da EOP, considerando urbanicidade e migração interna; b) a associação entre fatores de risco individuais, familiares e de área geográfica e a incidência de EOP; c) a ocorrência de mudanças genéticas em pacientes com EOP, em comparação com controles saudáveis e indivíduos em risco (irmãos saudáveis), utilizando técnicas de Genome Wide Associations; d) a ocorrência de interações entre os fatores sociais e genéticos na incidência de EOP.

Scientific publications

(18)

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

LOUREIRO, CAMILA MARCELINO; CORSI-ZUELLI, FABIANA; FACHIM, HELENE APARECIDA; SHUHAMA, ROSANA; DE SOUZA CHAGAS, NATALIA MOTA; MENEZES, PAULO ROSSI; DEL-BEN, CRISTINA MARTA; LOUZADA-JUNIOR, PAULO. Plasma prevalence of anti-N-methyl-d-aspartate receptor IgG antibodies in early stages of psychosis. Ciênc. saúde coletiva, v. 26, n. 3, p. 1085-1094, MAR 2021. (17/17480-6, 13/08216-2, 13/11167-3, 17/00624-5, 16/12195-9, 12/05178-0, 15/02948-7)

LOUREIRO, CAMILA MARCELINO; FACHIM, HELENE APARECIDA; CORSI-ZUELLI, FABIANA; SHUHAMA, ROSANA; JOCA, SAMIA; MENEZES, PAULO ROSSI; DALTON, CAROLINE F.; DEL-BEN, CRISTINA MARTA; LOUZADA-JUNIOR, PAULO; REYNOLDS, GAVIN P.. Epigenetic-mediated N-methyl-D-aspartate receptor changes in the brain of isolated reared rats. Epigenomics, v. 12, n. 22, NOV 2020. (13/08216-2, 16/12195-9, 12/05178-0, 13/11167-3, 12/17626-7, 15/02948-7, 19/13229-2, 17/00624-5)

SHUHAMA, ROSANA; ROCHA, VICTORIA HELENA STELZER; LOUREIRO, CAMILA MARCELINO; CORSI-ZUELLI, FABIANA; SANTOS, JAIR LICIO FERREIRA; MENEZES, PAULO ROSSI; DEL-BEN, CRISTINA MARTA. Social and clinical features associated with duration of untreated psychosis in the Brazilian STREAM study. ASIAN JOURNAL OF PSYCHIATRY, v. 65, p. 3-pg., 2021-09-07. (19/13229-2, 13/11167-3, 12/05178-0)

CAMILA MARCELINO LOUREIRO; FABIANA CORSI-ZUELLI; HELENE APARECIDA FACHIM; ROSANA SHUHAMA; ADRIELLE MARTINS DE OLIVEIRA; PAULO ROSSI MENEZES; CAROLINE F. DALTON; PAULO LOUZADA-JUNIOR; SINTIA IOLE BELANGERO; FERNANDA COELI-LACCHINI; et al. Lifetime cannabis use and childhood trauma increase risk of psychosis in carriers of CNR1 genetic variants: findings from the STREAM study. Revista Brasileira de Psiquiatria, v. 45, n. 3, p. 226-235, 2023-07-03. (15/02948-7, 12/05178-0, 21/07448-3, 20/15752-1, 17/00624-5, 13/11167-3, 13/08216-2, 19/13229-2)

CORSI-ZUELLI, FABIANA; LOUREIRO, CAMILA MARCELINO; SHUHAMA, ROSANA; FACHIM, HELENE APARECIDA; MENEZES, PAULO ROSSI; LOUZADA-JUNIOR, PAULO; MONDELLI, VALERIA; DEL-BEN, CRISTINA MARTA. Cytokine profile in first-episode psychosis, unaffected siblings and community-based controls: the effects of familial liability and childhood maltreatment. PSYCHOLOGICAL MEDICINE, v. 50, n. 7, p. 1139-1147, MAY 2020. (12/05178-0, 16/12195-9, 13/11167-3, 13/08216-2, 17/17480-6, 15/02948-7)

CORSI-ZUELLI, FABIANA; FACHIM, HELENE APARECIDA; LOUREIRO, CAMILA MARCELINO; SHUHAMA, ROSANA; BERTOZI, GIULIANO; JOCA, SAMIA REGIANE LOURENGO; MENEZES, PAULO ROSSI; LOUZADA-JUNIOR, PAULO; DEL-BEN, CRISTINA MARTA. Prolonged Periods of Social Isolation From Weaning Reduce the Anti-inflammatory Cytokine IL-10 in Blood and Brain. FRONTIERS IN NEUROSCIENCE, v. 12, JAN 11 2019. (13/11167-3, 13/08216-2, 17/00624-5, 16/12195-9, 15/02948-7, 17/17480-6, 12/05178-0)

CORSI-ZUELLI, FABIANA; QUATTRONE, DIEGO; RAGAZZI, TACIANA CRISTINA CARVALHO; LOUREIRO, CAMILA MARCELINO; SHUHAMA, ROSANA; MENEZES, PAULO ROSSI; LOUZADA-JUNIOR, PAULO; DEL-BEN, CRISTINA MARTA. Transdiagnostic dimensions of symptoms and experiences associated with immune proteins in the continuity of psychosis. PSYCHOLOGICAL MEDICINE, v. 54, n. 9, p. 13-pg., 2024-02-28. (12/05178-0, 19/13229-2, 21/07448-3, 20/15752-1, 13/08216-2, 13/11167-3)

LOUREIRO, CAMILA MARCELINO; CORSI-ZUELLI, FABIANA; FACHIM, HELENE APARECIDA; SHUHAMA, ROSANA; DE SOUZA CHAGAS, NATALIA MOTA; MENEZES, PAULO ROSSI; DEL-BEN, CRISTINA MARTA; LOUZADA-JUNIOR, PAULO. Plasma prevalence of anti-N-methyl-d-aspartate receptor IgG antibodies in early stages of psychosis. Ciênc. saúde coletiva, v. 26, n. 3, p. 10-pg., 2021-03-01. (15/02948-7, 17/17480-6, 12/05178-0, 13/11167-3, 13/08216-2, 16/12195-9, 17/00624-5)

SHUHAMA, ROSANA; RODRIGUES DO CARMO, LORENA DE SOUZA; BUSATTO FILHO, GERALDO; FERREIRA SANTOS, JAIR LICIO; DEL-BEN, CRISTINA MARTA; SCAZUFCA, MARCIA; MENEZES, PAULO ROSSI. From where we came: Absence of internal migration effect on psychosis in two case-control Brazilian samples. SCHIZOPHRENIA RESEARCH, v. 212, p. 241-242, OCT 2019. (13/11167-3, 12/05178-0)

FACHIM, HELENE A.; LOUREIRO, CAMILA M.; CORSI-ZUELLI, FABIANA; SHUHAMA, ROSANA; LOUZADA, JR., PAULO; MENEZES, PAULO ROSSI; DALTON, CAROLINE F.; DEL-BEN, CRISTINA MARTA; REYNOLDS, GAVIN P.. GRIN2B promoter methylation deficits in early-onset schizophrenia and its association with cognitive function. Epigenomics, v. 11, n. 4, p. 401-410, MAR 2019. (12/05178-0, 12/17626-7, 16/12195-9, 13/11167-3, 13/08216-2, 17/17480-6, 15/02948-7)

LOUREIRO, CAMILA MARCELINO; DA ROZA, DAIANE LEITE; CORSI-ZUELLI, FABIANA; SHUHAMA, ROSANA; FACHIM, HELENE APARECIDA; SIMOES-AMBROSIO, LIVIA MARIA CORDEIRO; DEMINICE, RAFAEL; JORDAO, ALCEU AFONSO; MENEZES, PAULO ROSSI; DEL-BEN, CRISTINA MARTA; et al. Plasma amino acids profile in first-episode psychosis, unaffected siblings and community-based controls. SCIENTIFIC REPORTS, v. 10, n. 1, DEC 8 2020. (13/11167-3, 16/12195-9, 18/07581-2, 17/00624-5, 15/02948-7, 19/13229-2)

SAN-MARTIN, RODRIGO; ZIMIANI, MARIA INES; DE AVILA, MILTON AUGUSTO VENDRAMINI; SHUHAMA, ROSANA; DEL-BEN, CRISTINA MARTA; MENEZES, PAULO ROSSI; FRAGA, FRANCISCO JOSE; SALUM, CRISTIANE. Early Schizophrenia and Bipolar Disorder Patients Display Reduced Neural Prepulse Inhibition. BRAIN SCIENCES, v. 12, n. 1, JAN 2022. (12/05178-0, 13/11167-3)

FACHIM, HELENE A.; CORSI-ZUELLI, FABIANA; LOUREIRO, CAMILA M.; IAMJAN, SRI-ARUN; SHUHAMA, ROSANA; JOCA, SAMIA; MENEZES, PAULO ROSSI; HEALD, ADRIAN; LOUZADA-JUNIOR, PAULO; DALTON, CAROLINE F.; et al. Early-life stress effects on BDNF DNA methylation in first-episode psychosis and in rats reared in isolation. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v. 108, JUN 8 2021. (12/05178-0, 12/17626-7, 13/11167-3, 17/00624-5, 13/08216-2, 19/13229-2, 17/17480-6, 15/02948-7)

LOUREIRO, CAMILA M.; FACHIM, HELENE A.; CORSI-ZUELLI, FABIANA; SHUHAMA, ROSANA; MENEZES, PAULO R.; DALTON, CAROLINE F.; DEL-BEN, CRISTINA M.; REYNOLDS, GAVIN P.; LOUZADA-JUNIOR, PAULO. The relationship of childhood trauma and DNA methylation of NMDA receptor genes in first-episode schizophrenia. Epigenomics, v. 13, n. 12, p. 927-937, JUN 2021. (12/05178-0, 13/11167-3, 17/00624-5, 16/12195-9, 19/13229-2, 15/02948-7, 13/08216-2)

SAN-MARTIN, RODRIGO; ZIMIANI, MARIA INES; NOYA, CLAUDEMIRO; VENDRAMINI AVILA, MILTON AUGUSTO; SHUHAMA, ROSANA; DEL-BEN, CRISTINA MARTA; MENEZES, PAULO ROSSI; FRAGA, FRANCISCO JOSE; SALUM, CRISTIANE. A Method for Simultaneous Evaluation of Muscular and Neural Prepulse Inhibition. FRONTIERS IN NEUROSCIENCE, v. 12, SEP 26 2018. (13/11167-3, 12/05178-0)

CORSI-ZUELLI, FABIANA; HENRIQUES SCHNEIDER, AYDA; SANTOS-SILVA, THAMYRIS; MARCELINO LOUREIRO, CAMILA; SHUHAMA, ROSANA; ROSSI MENEZES, PAULO; SILVEIRA GUIMARAES, FRANCISCO; VILLELA GOMES, FELIPE; QUEIROZ CUNHA, FERNANDO; LOUZADA, PAULO; et al. Increased blood neutrophil extracellular traps (NETs) associated with early life stress: translational findings in recent-onset schizophrenia and rodent model. TRANSLATIONAL PSYCHIATRY, v. 12, n. 1, p. 11-pg., 2022-12-26. (13/08216-2, 13/11167-3, 18/17597-3, 12/05178-0, 19/19190-0, 19/13229-2, 21/07448-3, 20/15752-1, 17/24304-0)

RAGAZZI, TACIANA CRISTINA CARVALHO; SHUHAMA, ROSANA; DA SILVA, PEDRO HENRIQUE RODRIGUES; CORSI-ZUELLI, FABIANA; LOUREIRO, CAMILA MARCELINO; DA ROZA, DAIANE LEITE; LEONI, RENATA FERRANTI; MENEZES, PAULO ROSSI; DEL-BEN, CRISTINA MARTA. Neurocognition and brain functional connectivity in a non-clinical population-based sample with psychotic experiences. SCHIZOPHRENIA RESEARCH, v. 267, p. 9-pg., 2024-03-27. (17/22212-0, 19/13229-2, 12/05178-0, 18/07581-2, 20/15752-1, 21/07448-3, 13/11167-3)

CORSI-ZUELLI, FABIANA; MARQUES, LEONARDO; DA ROZA, DAIANE LEITE; LOUREIRO, CAMILA MARCELINO; SHUHAMA, ROSANA; DI FORTI, MARTA; MENEZES, PAULO ROSSI; LOUZADA-JUNIOR, PAULO; DEL-BEN, CRISTINA MARTA. The independent and combined effects of cannabis use and systemic inflammation during the early stages of psychosis: exploring the two-hit hypothesis. PSYCHOLOGICAL MEDICINE, v. N/A, p. 11-pg., 2021-03-19. (12/05178-0, 13/11167-3, 13/08216-2, 19/13229-2, 18/07581-2)