Synthesis and biological evaluation of functionalized pyrrolidines and piperidines having potential inhibitory activity against alpha-glycosidase, from Morita-Baylis-Hillman adducts

• Grant number: 13/06757-6
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: July 01, 2013
• End date: March 31, 2017
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Fernando Antonio Santos Coelho
• Grantee: Érica Cristina da Silva
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

This PhD project has as main target the development of a new approach for the synthesis of functionalizated pyrrolidines and piperidines using suitable Morita-Baylis-Hillman, as building blocks. Poly-hydroxylated pyrrolidines and piperidines show a remarkable inhibitory activity against some glycosidases and other enzymes associated with the metabolismo of N-linked glycoproteins. These heterocycles can be used as prototype for the design of new medicines to the treatment of diabetes, cancer, viral infections and lysosomal storage disorders. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DA SILVA, ERICA C.; YAMAKAWA, NATHALIA C. G.; DOS SANTOS, ALCINDO A.; COELHO, FERNANDO. Short and Diastereoselective Total Synthesis of the Polyhydroxylated Pyrrolidine LAB-1: A Potent -Glycosidase Inhibitor. SYNTHESIS-STUTTGART, v. 49, n. 21, p. 4869-4875, NOV 2017. (13/10449-5, 13/06757-6, 16/09579-0, 13/07600-3)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SILVA, Érica Cristina da. Studies aiming at the synthesis of pyrrolidines and piperidines with potential inhibitory activity of alpha-glycosidases. 2017. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Instituto de Química Campinas, SP.