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Synthesis and biological evaluation of functionalized pyrrolidines and piperidines having potential inhibitory activity against alpha-glycosidase, from Morita-Baylis-Hillman adducts

Grant number: 13/06757-6
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): July 01, 2013
Effective date (End): March 31, 2017
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal researcher:Fernando Antonio Santos Coelho
Grantee:Érica Cristina da Silva
Home Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

This PhD project has as main target the development of a new approach for the synthesis of functionalizated pyrrolidines and piperidines using suitable Morita-Baylis-Hillman, as building blocks. Poly-hydroxylated pyrrolidines and piperidines show a remarkable inhibitory activity against some glycosidases and other enzymes associated with the metabolismo of N-linked glycoproteins. These heterocycles can be used as prototype for the design of new medicines to the treatment of diabetes, cancer, viral infections and lysosomal storage disorders. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DA SILVA, ERICA C.; YAMAKAWA, NATHALIA C. G.; DOS SANTOS, ALCINDO A.; COELHO, FERNANDO. Short and Diastereoselective Total Synthesis of the Polyhydroxylated Pyrrolidine LAB-1: A Potent -Glycosidase Inhibitor. SYNTHESIS-STUTTGART, v. 49, n. 21, p. 4869-4875, NOV 2017. Web of Science Citations: 3.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.