Effects of nutritional supplementation with glutamine on intestinal permeability, systemic low-grade inflammation and consequences on body composition in elderly individuals

• Grant number: 13/04199-6
• Support Opportunities: Scholarships in Brazil - Master
• Start date: August 01, 2013
• End date: August 31, 2014
• Field of knowledge: Health Sciences - Nutrition
• Principal Investigator: Sandra Maria Lima Ribeiro
• Grantee: Angélica Marques de Pina Freitas
• Host Institution: Escola de Artes, Ciências e Humanidades (EACH). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Introduction: Recent studies have shown the central role of the gut in modulating systemic low-grade inflammation and possible consequences in free fat mass (FFM). Aims: To evaluate the effect of glutamine supplementation on body composition and inflammatory markers in elderly patients with some risk of frailty. Methods: A randomized double-blind study. Community-dwelling elderly will be recruited, distributed into two groups. One group will receive during the period of six months, the supplementation with glutamine and the other will receive a placebo (maltodextrin). Subjects will be evaluated at the start and at the end of experiment for: body mass index (BMI), the skinfolds and body circumferences, the biological fragility, body composition( by bioelectrical impedance analysis and DEXA), plasmatic inflammatory cytokines (IL -1, IL-6 and TNF-alfa), intestinal permeability and food intake. Statistical analysis will be evaluated with appropriate test according to the type of data distribution.

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

FREITAS, Angélica Marques de Pina. Effects of supplementation with glutamine on systemic low-grade inflammation and body composition in elderly individuals. 2015. Master's Dissertation - Universidade de São Paulo (USP). Conjunto das Químicas (IQ e FCF) (CQ/DBDCQ) São Paulo.