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The impact of an Obstetric/Hematology Assistance Protocol in maternal and perinatal outcomes in women with Sicke Cell Disease

Grant number: 13/06418-7
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): July 01, 2013
Effective date (End): June 30, 2014
Field of knowledge:Health Sciences - Medicine - Maternal and Child Health
Principal Investigator:Maria Laura Costa Do Nascimento
Grantee:Mariana Abreu de Andrade
Home Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Background: high-risk pregnancies require a close monitoring by a specialized prenatal care in order to attempt the reduction of maternal and neonatal morbidity and mortality Sickle cell disease is a hemoglobinopathy associated with severe complications during pregnancy such as vaso-occlusive pain, with prepartum and postpartum crises, increased number of urinary tract infections, pulmonary complications, anemia, preeclampsia, preterm birth and intrauterine growth restriction (IGR). Objective: to evaluate the impact of an Obstetric/Hematology Assistance Protocol in patients with sickle cell disease followed by the specialized prenatal care at Professor Doutor José Aristodemo Pinotti Woman's Hospital CAISM/Unicamp. Methods: a retrospective longitudinal study analyzing the medical records of pregnant women followed by the prenatal care before (2004-2012) and after (2012-2013) the protocol introduction. Results: the dependent variables will be described with their categories (patients from the two time periods specified, patient Hb AS, Hb SS, Hb SC e Hb S/Tal), with the absolute frequency by group and the category of each independent variable. Finally,a multinominal regression model will be estimated with the independent variables associated with the mother and fetus's morbi-mortality, with adjusted OR and a 95% confidence interval. SPSS and Stata softwares will be used to organize and analyze the records. (AU)