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High-fat diet, inflammation and metabolic programming: effects on insulin signaling in recently weaned and adult mice

Grant number: 13/12003-4
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): August 01, 2013
Effective date (End): December 31, 2014
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Adriana Souza Torsoni
Grantee:Thais de Fante
Host Institution: Faculdade de Ciências Aplicadas (FCA). Universidade Estadual de Campinas (UNICAMP). Limeira , SP, Brazil


Since obesity has become a public health problem, studies have focused increasingly trying to unravel the damage that fat accumulation can cause in the body. Today, it is known that obesity is associated with the development of a number of other diseases. Among the triggering factors of obesity, the consumption of high fat diet has increased in the population. Recent studies have shown the relationship between the consumption of high fat diet in periods such as pregnancy and lactation and damage in molecular mechanisms of offspring. Among these mechanisms, insulin signaling pathway has shown impaired due to characteristic subclinical inflammation of obesity. However, the effects of excessive body fat on insulin signaling of recently weaned animals and mice re-exposed to the high-fat diet in adulthood in central and peripheral tissues have not yet been fully characterized in the literature. In this context, this study will investigate the effects of metabolic programming and the reintroduction of high fat diet in adulthood on insulin signaling of the offspring at 28 and 82 days of life. Considering the effects of metabolic programming and the effects of direct consumption of high fat diet, we believe that both may cause potential changes in the mechanisms studied, however, metabolic programming would be a crucial factor for the development and aggravation of molecular disorders in adulthood. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE FANTE, THAIS; SIMINO, LAIS ANGELICA; REGINATO, ANDRESSA; PAYOLLA, TANYARA BALIANI; GUSTAVO VITORELI, DEBORA CRISTINA; DE SOUZA, MONIQUE; TORSONI, MARCIO ALBERTO; MILANSKI, MARCIANE; TORSONI, ADRIANA SOUZA. Diet-Induced Maternal Obesity Alters Insulin Signalling in Male Mice Offspring Rechallenged with a High-Fat Diet in Adulthood. PLoS One, v. 11, n. 8, . (13/12003-4, 11/22156-7)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
FANTE, Thais de. High-fat diet, inflammation and metabolic programming: effects on insulin signaling in newly weaned and adult offspring of mice. 2015. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Aplicadas Limeira, SP.

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