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Assessment of the activity and concentration of the carbonic anhydrase VI enzyme and its relationship with dental caries in obese children

Grant number: 13/03124-2
Support type:Scholarships in Brazil - Master
Effective date (Start): September 01, 2013
Effective date (End): April 30, 2015
Field of knowledge:Health Sciences - Dentistry - Social and Preventive Dentistry
Principal researcher:Silvia Helena de Carvalho Sales Peres
Grantee:Ana Célia Panveloski Costa
Home Institution: Faculdade de Odontologia de Bauru (FOB). Universidade de São Paulo (USP). Bauru , SP, Brazil


Obesity and dental caries are public health problems which achieve the infants. The scientific literature shows controversial data about the relationship between these diseases. The carious process can be influenced by the saliva action, either by quality and quantity changes, since it has important role at oral homeostasis. The calcium, phosphate and fluoride ions present on saliva assist the dental remineralization process and can modify the tooth structure susceptibility to dental caries progress. Besides these ions, the activity of the carbonic anhydrase VI enzyme may influence the buffer bicarbonate/phosphate capacity, considering that it penetrates in the dental biofilm and facilitate the acid neutralization by the salivary bicarbonate. Therefore, studies are necessary to correlate the dental caries and salivary characteristics with the obesity. Objectives: To identify the dental caries prevalence and relate it to the activity and concentration of carbonic anhydrase VI enzyme, salivary flow, calcium, phosphate and fluoride ions concentration on saliva, pH and buffer capacity of the salivary flow and quantity of biofilm in obese children. Methods: It will be selected 100 children aged 4-6 years, of both genders. Anthropometric analysis (BMI) will be performed to divide the groups. The children will be divided into two groups: G1 - obese (n=50) and G2 - normal (n=50). The oral examination will be conducted to evaluate dental caries, using two indexes (dmf-s and ICDAS II), and the biofilm quantity will be measured through the Quigley-Hein (Turesky-modification) Index. Further, two subgroups will be formed and in each group: FC - dental caries free (n=15) and C children with dental caries. Both subgroups will have a saliva sample collected for determination of pH, buffer capacity, phosphate, calcium and fluoride ions concentration and activity and concentration of carbonic anhydrase VI enzyme on saliva. The results will be presented at descriptive form and will be submitted to statistical tests Wilcoxon, Mann-Whitney and Spearman Correlation(p<0.05). (AU)

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
COSTA, Ana Célia Panveloski. Evaluation of the concentration of the carbonic anydrase VI and its relation with dental caries in obese children. 2015. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Odontologia de Bauru (FOB/SDB) Bauru.

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