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Modulation of chaperone mediated autophagy in hypothalamus of diet-induced obese mice.

Grant number: 13/10911-0
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): September 01, 2013
Effective date (End): December 31, 2017
Field of knowledge:Biological Sciences - Biochemistry - Metabolism and Bioenergetics
Principal Investigator:Marciane Milanski Ferreira
Grantee:Mariana Portovedo de Oliveira Araújo
Host Institution: Faculdade de Ciências Aplicadas (FCA). Universidade Estadual de Campinas (UNICAMP). Limeira , SP, Brazil
Associated scholarship(s):14/22726-6 - The role of fatty acids on hypothalamic autophagy regulation, BE.EP.DR


Obesity is nowadays a problem of public health worldwide and is determined by the accumulation of body fat mass. This fact is given by the loss of energy homeostasis, and the hypothalamus is the region of the brain responsible for coordinating food intake and energy expenditure by signaling peripheral hormones. It is known that this region suffers an inflammatory process during the development of obesity which is associated with activation of a cellular pathway related to the immune system, activation of TLR4 and also, with the induction of endoplasmic reticulum stress. Recently, it was also shown that change in the process of autophagy, important for the removal of dysfunctional proteins and organelles, can lead to changes in body because of the disruption of hypothalamic homeostasis. In peripheral tissues it was demonstrated that another type of autophagy, chaperone-mediated autophagy, is also decreased. This type of autophagy is responsible for the degradation of long-lived intracellular proteins and its failure causes the accumulation of dysfunctional proteins and formation of protein aggregates, which can direct the cell to apoptosis. Therefore, failure of chaperone-mediated autophagy may represent an important cellular dysfunction in the establishment of inflammation and cell death. The aim of this study is to investigate the modulation of chaperone-mediated autophagy in animals submitted to high-fat diet.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PORTOVEDO, M.; REGINATO, A.; MIYAMOTO, J. E.; SIMINO, L. A.; HAKIM, M. P.; CAMPANA, M.; LEAL, R. F.; IGNACIO-SOUZA, L. M.; TORSONI, M. A.; MAGNAN, C.; et al. Lipid excess affects chaperone-mediated autophagy in hypothalamus. Biochimie, v. 176, p. 110-116, . (13/10911-0, 14/11751-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
ARAÚJO, Mariana Portovedo de Oliveira. Regulation of hypothalamic chaperone-mediated autophagy in response to lipid overload. 2018. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Aplicadas Limeira, SP.

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