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Immunogenic Potential of the Ribosomal Protein P0 Against the Tick Rhipicephalus sanguineus (Acari:Ixodidae)in Dogs

Grant number: 13/10394-6
Support Opportunities:Scholarships in Brazil - Post-Doctorate
Effective date (Start): October 01, 2013
Effective date (End): September 30, 2016
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Pathology
Valor Concedido/Desembolsado (R$): 255,912.41 / 255,912.41
Principal Investigator:Rosangela Zacarias Machado
Grantee:Gustavo Seron Sanches
Host Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil

Abstract

The tick Rhipicephalus sanguineus has great medical and veterinary importance, since it acts as a vector of pathogens (viruses, bacteria, protozoa and nematodes), causing diseases in animals and in humans. The control of this tick has been mainly based on the use of chemical acaricides, however, the indiscriminate use has contributed to the selection of resistant ticks, in addition to high costs and environmental contamination. Vaccines have been considered a promising alternative for the control of ticks, although, to date, no commercial anti-tick vaccine available for use in dogs. With the advancement of molecular biology techniques, new molecules have emerged as candidates for vaccines for cattle ticks and potentially for dogs. Among these molecules highlights the ribosomal protein P0 of R. sanguineus and R. (B.) microplus. Recent studies have also shown the possibility of vaccines developed for a species of tick confer cross-protection for species genetically close. Thus, this study aims, in collaboration with the Centro de Ingeniería Genética y Biotecnologia de Havana - CIGB, Cuba, to evaluate the efficacy of peptide vaccines P0 against R. sanguineus in dogs in a challenge infestation through determination of the ticks biotic potential, histopathology of ticks fed on vaccinated hosts including the tick ultrastructure, histopathology of the tick attachment site, antibody anti-P0, and immunohistochemistry of unfed ticks and fed ticks on vaccinated hosts.

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SANCHES, GUSTAVO S.; EVORA, PATRICIA M.; MANGOLD, ATILIO J.; JITTAPALAPONG, SATTAPORN; RODRIGUEZ-MALLON, ALINA; GUZMAN, PEDRO E. E.; BECHARA, GERVASIO H.; CAMARGO-MATHIAS, MARIA I.. Molecular, biological, and morphometric comparisons between different geographical populations of Rhipicephalus sanguineus sensu lato (Acari: Ixodidae). Veterinary Parasitology, v. 215, p. 78-87, . (10/00415-8, 13/10394-6)
RODRIGUEZ MALLON, ALINA; JAVIER GONZALEZ, LUIS; ENCINOSA GUZMAN, PEDRO ENRIQUE; HENRIQUE BECHARA, GERVASIO; SERON SANCHES, GUSTAVO; POUSA, SATOMY; CABRERA, GLEYSIN; CABRALES, ANIA; GARAY, HILDA; MEJIAS, RAUL; et al. Functional and Mass Spectrometric Evaluation of an Anti-Tick Antigen Based on the P0 Peptide Conjugated to Bm86 Protein. PATHOGENS, v. 9, n. 6, . (13/10394-6)
SANCHES, GUSTAVO S.; ANDRE, MARCOS R.; DO PRADO, ANGELO P.; ALLEGRETTI, SILMARA M.; REMEDIO, RAFAEL N.; NUNES, PABLO H.; MACHADO, ROSANGELA Z.; BECHARA, GERVASIO H.; CAMARGO-MATHIAS, MARIA I.. Oocyte maturation in the sloth's giant tick Amblyomma varium (Acari: Ixodidae) in an ecological context. Experimental and Applied Acarology, v. 64, n. 4, p. 519-531, . (10/00415-8, 13/10394-6)
PATRICIA MARTINEZ ÉVORA; GUSTAVO SERON SANCHES; FELIX DAVID GUERRERO; ADALBERTO PÉREZ DE LEÓN; GERVÁSIO HENRIQUE BECHARA. Potencial imunogênico da aquaporina 1 de Rhipicephalus (Boophilus) microplus contra o carrapato Rhipicephalus sanguineus em cães domésticos. Revista Brasileira de Parasitologia Veterinária, v. 26, n. 1, p. 60-66, . (13/09792-7, 13/10394-6)

Please report errors in scientific publications list by writing to: cdi@fapesp.br.