| Grant number: | 13/10394-6 |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| Start date: | October 01, 2013 |
| End date: | September 30, 2016 |
| Field of knowledge: | Agronomical Sciences - Veterinary Medicine - Animal Pathology |
| Principal Investigator: | Rosangela Zacarias Machado |
| Grantee: | Gustavo Seron Sanches |
| Host Institution: | Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil |
Abstract The tick Rhipicephalus sanguineus has great medical and veterinary importance, since it acts as a vector of pathogens (viruses, bacteria, protozoa and nematodes), causing diseases in animals and in humans. The control of this tick has been mainly based on the use of chemical acaricides, however, the indiscriminate use has contributed to the selection of resistant ticks, in addition to high costs and environmental contamination. Vaccines have been considered a promising alternative for the control of ticks, although, to date, no commercial anti-tick vaccine available for use in dogs. With the advancement of molecular biology techniques, new molecules have emerged as candidates for vaccines for cattle ticks and potentially for dogs. Among these molecules highlights the ribosomal protein P0 of R. sanguineus and R. (B.) microplus. Recent studies have also shown the possibility of vaccines developed for a species of tick confer cross-protection for species genetically close. Thus, this study aims, in collaboration with the Centro de Ingeniería Genética y Biotecnologia de Havana - CIGB, Cuba, to evaluate the efficacy of peptide vaccines P0 against R. sanguineus in dogs in a challenge infestation through determination of the ticks biotic potential, histopathology of ticks fed on vaccinated hosts including the tick ultrastructure, histopathology of the tick attachment site, antibody anti-P0, and immunohistochemistry of unfed ticks and fed ticks on vaccinated hosts. | |
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