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Influence of the temperature in the toxicity of herbicides 500SC® and Gamit® in tadpoles of Eupemphix nattereri (Leptodactylidae) and Rhinella schneideri (Bufonidae)

Grant number: 13/16948-3
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): November 01, 2013
Effective date (End): January 31, 2017
Field of knowledge:Biological Sciences - Biochemistry - Enzymology
Principal Investigator:Eduardo Alves de Almeida
Grantee:Juliane Silberschmidt Freitas
Host Institution: Instituto de Biociências, Letras e Ciências Exatas (IBILCE). Universidade Estadual Paulista (UNESP). Campus de São José do Rio Preto. São José do Rio Preto , SP, Brazil
Associated scholarship(s):15/03545-3 - Disrupting effects of diuron and metabolite 3,4-DCA (3,4 - dichloroaniline) on tadpoles of Lithobates catesbeianus (Anura: Ranidae) exposed to thermal stress, BE.EP.DR


Temperature increase and other environmental effects caused by global climate changes have documented extensive impacts on many species and ecosystems of the world. Changes in the abiotic factors can potentially alter the nature and distribution of many contaminants in the environment, and, therefore, the main challenge of ecotoxicologists is to predict the risks established by these interactions in biological level. Pesticides include the major group of toxic agents found in natural systems, and many of these compounds are derived from maintenance of sugarcane crop in Brazil. In the northwest of São Paulo - Brazil, many species of amphibians are distributed in areas of agriculture and their reproductive activities are restricted to the rainy season, which coincides with the period of greatest environmental contamination. Sulfentrazone and clomazone are herbicides widely used in sugarcane crop; however, they are considered potent environmental contaminants due to their chemical properties. Thus, the aim of this study is to evaluate the influence of temperature on the toxicity of herbicides Boral SC500C® and Gamit® in tadpoles of northwestern São Paulo Eupemphix nattereri and Rhinella schneideri. The tadpoles will be exposed to contaminants in concentrations of 0.01, 0.05 and 0.1 mg/L, under different temperature gradients (28ºC, 32ºC and 36ºC), during 3 and 8 days. We will analyze oxidative stress parameters by evaluating enzymes superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), glucose-6-phosphate dehydrogenase (G6PDH) and lipid peroxidation. Enzymes activity of glutathione S-transferase (GST), acetylcholinesterase (AChE) and carboxylesterase (CBE) also will be evaluated and the rates of growth, development and malformations of the tadpoles will be recorded after exposure to different treatments. (AU)

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Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GREGORIO, L. S.; FREITAS, J. S.; FRANCO-BELUSSI, L.; DE OLIVEIRA, C.. LPS-induced alterations in reproductive organs and liver pigmentation in the toad Rhinella diptycha (Bufonidae). CANADIAN JOURNAL OF ZOOLOGY, v. 96, n. 12, p. 1336-1345, . (14/00946-4, 11/21519-9, 13/02067-5, 13/16948-3)
FREITAS, JULIANE SILBERSCHMIDT; FELICIO, ANDREIA ARANTES; TERESA, FABRICIO BARRETO; DE ALMEIDA, EDUARDO ALVES. Combined effects of temperature and clomazone (Gamit (R)) on oxidative stress responses and B-esterase activity of Physalaemus nattereri (Leiuperidae) and Rhinella schneideri (Bufonidae) tadpoles. Chemosphere, v. 185, p. 548-562, . (13/16948-3, 14/18825-9)
FELICIO, ANDREIA ARANTES; FREITAS, JULIANE SILBERSCHMIDT; SCARIN, JESSICA BOLPETI; ONDEI, LUCIANA DE SOUZA; TERESA, FABRICIO BARRETO; SCHLENK, DANIEL; DE ALMEIDA, EDUARDO ALVES. Isolated and mixed effects of diuron and its metabolites on biotransformation enzymes and oxidative stress response of Nile tilapia (Oreochromis niloticus). ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, v. 149, p. 248-256, . (11/52061-8, 13/16948-3, 14/18825-9)
FREITAS, JULIANE SILBERSCHMIDT; TERESA, FABRICIO BARRETO; DE ALMEIDA, EDUARDO ALVES. Influence of temperature on the antioxidant responses and lipid peroxidation of two species of tadpoles (Rhinella schneideri and Physalaemus nattereri) exposed to the herbicide sulfentrazone (Boral 500SC (R)). COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, v. 197, p. 32-44, . (13/16948-3)
GRIPP, HORTENSIA S.; FREITAS, JULIANE S.; ALMEIDA, EDUARDO A.; BISINOTI, MARCIA C.; MOREIRA, ALTAIR B.. Biochemical effects of fipronil and its metabolites on lipid peroxidation and enzymatic antioxidant defense in tadpoles (Eupemphix nattereri: Leiuperidae). ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, v. 136, p. 173-179, . (13/16948-3, 13/07937-8, 11/00574-1)
FREITAS, JULIANE S.; ALMEIDA, EDUARDO A.. Antioxidant Defense System of Tadpoles (Eupemphix nattereri) Exposed to Changes in Temperature and pH. ZOOLOGICAL SCIENCE, v. 33, n. 2, p. 186-194, . (13/16948-3)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
FREITAS, Juliane Silberschmidt. Influence of temperature on the toxicity of the herbicides sulfentrazone (Boral 500SC®) and clomazone (Gamit®) in tadpoles of Eupemphix nattereri (Leiuperidae) and Rhinella schneideri (Bufonidae). 2017. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Instituto de Biociências Letras e Ciências Exatas. São José do Rio Preto São José do Rio Preto.

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