Adipose tissue heterogeneity in cachexia: lipid profile in subcutaneous and visceral tissue of cancer patients

• Grant number: 13/17178-7
• Support Opportunities: Scholarships in Brazil - Master
• Start date: November 01, 2013
• End date: June 30, 2015
• Field of knowledge: Biological Sciences - Biochemistry - Metabolism and Bioenergetics
• Principal Investigator: Marilia Cerqueira Leite Seelaender
• Grantee: Daniela Mendes dos Reis Riccardi
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 12/50079-0 - Systemic inflammation in cachectic cancer patients: mechanisms and therapeutical strategies, a translational medicine approach, AP.TEM

Abstract

Cachexia is defined as a multifactorial syndrome, with continuous decrease of fat and muscle mass, which can not be totally reverted by conventional nutritional therapy, leading to progressive functional impairment. Around 80% of advanced cancer patients are affected by the syndrome, which a direct cause of death in 22-40% of the patients. The etiology of cachexia is complex, there is still no consensus of which factors are responsible to trigger and mantain the state. A possible contributor is the white adipose tissue (WAT), which suffers several alterations, such as morfological reorganization and increased lipolysis, thereby releasing non-esterified fatty acids (NEFA). It hás been demonstrated that the type of NEFA determinates different effects in the promotion of inflammation. Thus, the objective of the present study is to establish whether NEFA released by adipocytes in cachexia contributes to local, and thereafter, systemic inflammation in cancer patients. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DOS REIS RICCARDI, DANIELA MENDES; DAS NEVES, RODRIGO XAVIER; DE MATOS-NETO, EMIDIO MARQUES; CAMARGO, RODOLFO GONZALEZ; CAROLA CORREIA LIMA, JOANNA DARCK; RADLOFF, KATRIN; ALVES, MICHELE JOANA; FIGUEREDO COSTA, RAQUEL GALVAO; TOKESHI, FLAVIO; OTOCH, JOSE PINHATA; et al. Plasma Lipid Profile and Systemic Inflammation in Patients With Cancer Cachexia. FRONTIERS IN NUTRITION, v. 7, JAN 31 2020. (13/17178-7, 12/50079-0)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

RICCARDI, Daniela Mendes dos Reis. Lipid profile and systemic inflammation in cancer cachexia.. 2015. Master's Dissertation - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.