Immunomodulation and angiogenic activity of new thiazolidine compounds in wound healing process on MKR mice

• Grant number: 13/23140-2
• Support Opportunities: Scholarships abroad - Research Internship - Master's degree
• Start date: March 01, 2014
• End date: August 31, 2014
• Field of knowledge: Biological Sciences - Biochemistry
• Principal Investigator: Dulcineia Saes Parra Abdalla
• Grantee: Jacqueline Cavalcante Silva
• Supervisor: Marcelo G. Bonini
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Institution abroad: University of Illinois at Chicago (UIC), United States
• Associated to the scholarship: 12/14360-6 - Investigation of the effects of new thiazolidinediones in animal model of metabolic syndrome., BP.MS

Abstract

Preliminary results obtained in the Masters project "Investigation of new thiazolidine compounds effects in animal model of metabolic syndrome", demonstrated that this new thiazolidine compound, GQ-11, has in vivo immunomodulatory, anti-inflammatory and hypoglycemic effects, besides of angiogenic actions showed in previous in vitro studies of our group, what predicts a promising therapeutic strategy in wound healing, from homeostasis promotion at healing process. So, to expand this investigation, a collaboration between the Clinical Biochemistry Laboratory, supervised by Prof. Dulcineia Saes Parra Abdalla at the School of Pharmaceutical Sciences of University of São Paulo and the Cardiology and Pharmacology Laboratory, supervised by Prof. Marcelo Bonini, at University of Illinois at Chicago (UIC) was established to develop complementary studies to investigate the actions of the new thiazolidine compounds (GQ-11, GQ-02, GQ-177 and Lyso-7) on healing process by using MKR mice. (AU)