EFFECTS OF PHYSICAL EXERCISE ON THE SENSITIVITY OF GLUCOSE HYPOTHALAMUS IN RATS: ROLE OF PROTEIN ALPHA HIF2

• Grant number: 13/20052-5
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: December 01, 2013
• End date: November 30, 2017
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Eduardo Rochete Ropelle
• Grantee: Vagner Ramon Rodrigues Silva
• Host Institution: Faculdade de Ciências Aplicadas (FCA). Universidade Estadual de Campinas (UNICAMP). Limeira , SP, Brazil
• Associated scholarship(s): 16/05460-8 - The effects of exercise on glucose sensitivity in the hypothalamus of rats: the role of the protein alpha HIF2, BE.EP.DR

Abstract

In mammals, the food intake and energy expenditure are strongly regulated for specifically neurons localized in the hypothalamus. The hypothalamus controls the energy food and energy expenditure through of hormonal and nutritional signals. A main nutrient related the food intake control is the glucose. Studies link that the lost selective of glucose sensibility in the hypothalamic neurons are related the hyperphagia and obesity. Recently, the HIF2± emerged as regulated important maintenance of glucose sensibility in hypothalamic neurons. The loss of function of this molecule reduces the ability of neurons detect the presence of glucose, results in increase of food intake and body weight in mice. In this context, the maintenance of neuronal HIF2± can be considerate a determinate strategy for maintenance of lean phenotype. At the same time, the physical exercise is considered a main contributor to the control of body weight and energy expenditure. However the effects of physical exercise about the glucose sensibility in the central nervous systems (CNS) remain unexplored. Thus, the objective of this study is investigates the effect of physical exercise in the glucose sensibility in the hypothalamus of rats and evaluates the hypothalamic HIF2± protein expression.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SILVA, VAGNER R. R.; MICHELETTI, THAYANA O.; KATASHIMA, CARLOS K.; LENHARE, LUCIENE; MORARI, JOSEANE; MOURA-ASSIS, ALEXANDRE; DE LIMA-JUNIOR, JOSE C.; CAMARGO, JULIANA A.; PASSOS, GABRIELA R.; GASPAR, RODRIGO S.; et al. Exercise activates the hypothalamic S1PR1-STAT3 axis through the central action of interleukin 6 in mice. Journal of Cellular Physiology, v. 233, n. 12, p. 9426-9436, DEC 2018. (16/01089-3, 13/20052-5, 11/09656-0)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SILVA, Vagner Ramon Rodrigues. The effects of physical exercise about the glucose sensing in the hypothalamus of rats: the role of HIF2 alpha. 2018. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Aplicadas Limeira, SP.