Analysis of monocyte chemotactic protein-3 (CCL7) in hyperglycemic pregnant women with urinary incontinence: prospective cohort from pregnancy to six months postpartum

• Grant number: 12/25060-3
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: December 01, 2013
• End date: February 28, 2017
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal Investigator: Marilza Vieira Cunha Rudge
• Grantee: Fernanda Piculo
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

The mild gestational hyperglycemia (MGH) and gestational diabetes mellitus (GDM), referred as gestational hyperglycemia in this study, have important consequences for the mother, fetus and newborn. The association between gestational hyperglycemia and urinary incontinence is scarce in the literature. Our academic research group "Diabetes and Pregnancy - Clinical and Experimental", from Botucatu Medical School, UNESP, has studied the translational aspects of gestational hyperglycemia related to urinary incontinence in females and in animal models. The results help to elucidate the pathophysiological mechanisms that lead to female pelvic floor disorders in women with GDM and HGL, but there is need for further research to expand the understanding of the phenomena that result in better care for patients. Whereas monocyte chemotactic protein-3 (CCL7) is an important factor for the recovery mechanism of urinary incontinence, our hypothesis is that patients with GDM or HGL present changes in the CCL7 levels and delay/prevents migration of mesenchymal stem cells to the site of injury caused by IU, causing consequences in the postpartum period. Thus, the purpose of this study is to trace the CCL7 levels profile in hyperglycemic pregnant women with urinary incontinence since the beginning of pregnancy up to six months postpartum and to examine the correlation between the progression of UI and serum levels of CCL7. This identification may indicate CCL7 as a possible biomarker of recovery UI in hyperglycemic women during pregnancy and in the postpartum period and subsequently establish effective therapeutic intervention with consistent pathophysiological basis. Statistical analysis and the choice by comparing tests between variables and groups will be executed respecting the presuppositions determined by the results, characteristics and behavior of the variables. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PICULO, FERNANDA; MARINI, GABRIELA; VESENTINI, GIOVANA; MORCELI, GLILCIANE; DAMASCENO, DEBORA C.; SOBREVIA, LUIS; BARBOSA, ANGELICA M. P.; RUDGE, MARILZA V. C.. Pregnancy-specific urinary incontinence in women with gestational hyperglycaemia worsens the occurrence and severity of urinary incontinence and quality of life over the first year post partum. EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, v. 252, p. 8-pg., 2020-09-01. (12/25060-3)

RUDGE, M.; PICULO, F.; MARINI, G.; VESENTINI, V.; PRUDENCIO, C.; HALLUR, R.; BARBOSA, B.. ASSOCIATION BETWEEN GESTATIONAL DIABETES MELLITUS AND PREGNANCY-SPECIFIC URINARY INCONTINENCE: SEVERITY AND IMPACT ON THE QUALITY OF LIFE OVER THE FIRST YEAR POSTPARTUM. NEUROUROLOGY AND URODYNAMICS, v. 39, p. 2-pg., 2020-07-01. (16/01743-5, 12/25060-3)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

PICULO, Fernanda. Analysis of monocyte chemotactic protein-3 (CCL7) in Hyperglycemic pregnant women with urinary incontinence: prospective cohort of pregnancy up to the first year postpartum. 2017. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Medicina. Botucatu Botucatu.