|Support type:||Scholarships in Brazil - Scientific Initiation|
|Effective date (Start):||December 01, 2013|
|Effective date (End):||November 30, 2014|
|Field of knowledge:||Biological Sciences - Genetics - Human and Medical Genetics|
|Principal Investigator:||Lucas Trevizani Rasmussen|
|Grantee:||Mariane Avante Ferraz|
|Home Institution:||Pró-Reitoria de Pesquisa e Pós-Graduação. Universidade do Sagrado Coração (USC). Bauru , SP, Brazil|
Duodenal ulcer-promoting gene A (dupA), is a novel virulence factor, in Helicobacter pylori and was associated with duodenal ulcer development and reduced risk for gastric carcinoma in some populations. In additional, E-caderin gene seems to be associated with infiltrative and metastatic ability of gastric tumors. Previous studies suggesting that gene inactivation of E-cadherin by H. pylori may be related to gastric carcinogenesis. Therefore, the aims of this study are: to determine the presence of dupA gene and evaluate association with other virulence factors such as cagA, vacA previous detected, and analysis the gene expression of E-cadherin gene in 110 samples from gastric biopsies of adults patients with peptic symptoms and / or gastric cancer, in order to correlate the expression of E-Caderin gene and dupA virulence factor on the development and in the progression of gastric changes. The development of this approach may open new perspectives for the characterization of factors involved in peptic diseases, gene regulation, as well as to elucidate the interaction among genes involved in gastric diseases, improving the understanding of the pathophysiological mechanisms of these diseases.