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A new anthropometric measurement to estimate visceral adipose component in Metabolic Syndrome

Grant number: 13/07894-7
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): December 01, 2013
Effective date (End): November 30, 2014
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Rosa Ferreira dos Santos
Grantee:Raquel Pissiguelli
Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil


The Metabolic Syndrome (MS) is a set of cardiovascular risk factors associated with central adiposity and insulin resistance (IR), visceral obesity as being directly responsible for IR, regarded as the pathophysiological basis of MS. The prevalence of MS is not yet well established in Brazil, but the MS is a major challenge in terms of public health, a study is essential to assist in the diagnosis and prevention of disease in order to reduce the excessive spending on public health in the country . Objective - this study aims to establish and validate a clinical method practical, inexpensive, to quantify visceral fat using measures of waist circumference, and abdominal and suprailiac skinfolds, the latter considered standard, subtracting the subcutaneous component, and specific aims to propose a new method, based on a mathematical model that quantifies the component subcutaneous abdominal and visceral fat from the method fold and waist circumference correlate them with CT of the abdomen from a mathematical model. Methods - for the research will be evaluated patients 60 male volunteers, between 18 and 60 years, participants of the League of Metabolic Syndrome (LSM), the Clinic of Endocrinology, Hospital das Clinicas (HC), Faculty of Medicine, University of São Paulo (USP). Methodologies of data collection were selected computed tomography examination gold standard, and measures of waist circumference and skin thickness abdominal and suprailiac. The data will be processed by the program Advanced Workstation (GE HEALTHCARE). Results - based on the processed data it will be construct a correlation curve between the data of the circumference of total abdominal subcutaneous fat on the subfraction with the respective areas determined through the CT scan in order to obtain a mathematical formula, where anthropometric measures defined in this study are able to predict with high accuracy, the amount of abdominal fat and thus define a more accurate diagnosis of MS. Moreover, it will be tried to establish whether the component interferes with the evaluation of the subcutaneous total abdominal circumference as adequate parameter for the quantification of visceral fat, and a subtraction is required for more precise diagnosis of the metabolic syndrome. Thus, this study aims to seek a simple and inexpensive method for the diagnosis of MS in the population, prioritizing public health policies and directing preventive strategies, thereby avoiding unnecessary spending that address a budget deficit already, and at the same time, promote an optimization of funds, with greater clinical effectiveness and greater benefits for the whole population.(AU)

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