Evaluation of the antiproliferative effects of Perillyl Alcohol in Medulloblastoma cell lines

• Grant number: 13/23881-2
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: January 01, 2014
• End date: December 31, 2015
• Field of knowledge: Biological Sciences - Genetics - Human and Medical Genetics
• Principal Investigator: María Sol Brassesco Annichini
• Grantee: Marcela de Oliveira Silva
• Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Medulloblastoma (MB) is a malignant brain tumor with high prevalence among children, (highest incidence 8 years old). Standard treatment consists of maximum surgical resection, followed by local and craniospinal radiotherapy and adjuvant chemotherapy. Children under 3 years of age, however, are more difficult to treat because the irradiation cannot be used due to the neurological damage associated with it. Thus, despite conventional treatments to improve survival rates, about one third of patients remain incurable with many of these treatments causing significant damage to long-term survivors. Perillyl alcohol (POH), a monoterpene found at low concentrations in various plants has shown beneficial effects for the treatment of various tumor types. Intranasal administration of POH is a practical and non-invasive strategy, which has shown usefulness in glioblastomas due to its ability to cross the blood-brain barrier, reaching the central nervous system, and reducing the systemic and side effects without significantly affecting normal cells. Nonetheless, the effects of this new treatment in MB are still unknown. Thus, the present project aims to analyze the in vitro effects of POH in MB cell lines on cell death, invasion and proliferation.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SILVA, MARCELA DE OLIVEIRA; DE SOUSA, GRAZIELLA RIBEIRO; SIMOES, SARAH CAPELUPE; NICOLUCCI, PATRICIA; TAMASHIRO, EDWIN; SAGGIORO, FABIANO; DE OLIVEIRA, RICARDO SANTOS; BRASSESCO, MARIA SOL. Perillyl alcohol for pediatric TP53- and RAS-mutated SHH-medulloblastoma: an in vitro and in vivo translational pre-clinical study. CHILD'S NERVOUS SYSTEM, v. 37, n. 7, p. 2163-2175, JUL 2021. (16/08125-5, 13/23881-2)