Effect of magnetic fields on cell proliferation and its application as a device for tissue engineering

• Grant number: 13/19748-5
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: December 01, 2013
• End date: July 06, 2014
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Luiz Henrique Catalani
• Grantee: Hermann Nuss
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 11/21442-6 - Synthetic and natural polymers applied to tissue engineering, AP.TEM

Abstract

The objective of this project is the development of a biomaterial with advanced properties for use in biomedical engineering. It is based on the recent demonstration of an important effect of external magnetic field on cell proliferation of fibroblasts over a hybrid scaffold made of xanthan and magnetite nanoparticles a result of collaboration between the groups of Prof. Luiz Catalani and Prof. Denise Petri. The intention here is an in depth study of the effect of magnetic field on the enhanced cell proliferation in order to understand its basics and to promote its optimization. Using electrospinning as processing technique, it is intended the application of this new knowledge to develop a hybrid support made of PLLA and/or xanthan containing mineral phases such as magnetite and hydroxyapatite and that it can be successful applied to bone regeneration.