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Efficacy of curcumin-mediated photodynamic inactivation against dental biofilms and evaluation of possible changes on the properties of composite resins and dental surface

Grant number: 13/15770-6
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): January 01, 2014
Effective date (End): July 31, 2016
Field of knowledge:Health Sciences - Dentistry - Dental Clinics
Principal Investigator:Lívia Nordi Dovigo
Grantee:Carolina Santezi Neto
Host Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil


Formation of dental biofilm is the main factor associated to oral infections development. Although topic antimicrobials, such as chlorhexidine (CHX), have been used to decontaminate the oral surfaces, they may promote adverse effects on hard and soft tissues as well as the possibility of promoting microorganism resistance. Thus, the investigation of alternative antimicrobial treatments, as the Photodynamic Inactivation (PDI), is relevant to dental sciences. Previous research suggested that the Curcumin may be a promising photosensitizer for PDI, but there are some aspects that need to be better evaluated. The aim of this study is to assess the efficacy of Curcumin-mediated PDI against dental biofilms and the existence of possible negative effects of PDI on the properties of composite resins and dental surface. The research will be divided into 3 consecutive studies. The study I aims to evaluate the PDI efficacy using different Curcumin formulations (liquid or hydrogel) and concentrations (20, 40, 60 and 80µM) on dual-species in vitro biofilm. With the results of Study I, it will be possible to select the best PDI protocol (curcumin concentration and formulation) to promote quantitative decrease of the microorganisms in the biofilm. The Study II will assess the effect of the previous defined protocol of Curcumin-mediated PDI on the color stability, surface roughness and microhardness of dental surface and different composite resins. The study III will use an in situ model of dental biofilm that will allow the evaluation of the PDI protocol for inactivations of multispecies biofilms formed naturally in different subjects. The multilevel design will allow the evaluation of both the efficacy of PDI on natural dental biofilm and the possible effect of inter-individual microbiota differences on the PDI efficacy. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SANTEZI, CAROLINA; REINA, BARBARA DONADON; DE ANNUNZIO, SARAH RAQUEL; CALIXTO, GIOVANA; CHORILLI, MARLUS; DOVIGO, LIVIA NORDI. Photodynamic potential of curcumin in bioadhesive formulations: Optical characteristics and antimicrobial effect against biofilms. Photodiagnosis and Photodynamic Therapy, v. 35, . (13/15770-6, 15/24112-8)
REINA, BARBARA DONADON; SANTEZI NETO, CAROLINA; GARCIA, PATRICIA PETROMILLI NORDI SASSO; CHORILLI, MARLUS; CALIXTO, GIOVANA MARIA FIORAMONTI; DOVIGO, LIVIA NORDI. Bioadhesive Curcumin-Mediated Photodynamic Inactivation and Its Potential to Cause Undesirable Effects on Dental and Restorative Surfaces. PHARMACEUTICS, v. 13, n. 9, . (13/15770-6)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SANTEZI NETO, Carolina. Effectiveness of photodynamic inactivation mediated by curcumin in different formulations on biofilm and effect on the properties of restorative materials and enamel. 2016. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Odontologia. Araraquara Araraquara.

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