Expression and polymorphic variants analysis of fibronectin 1 and tenascin-C genes in rotator cuff tear

• Grant number: 13/23332-9
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: January 01, 2014
• End date: December 31, 2014
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: Mariana Ferreira Leal
• Grantee: Leonor Isabel Casilla Loyola
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated research grant: 11/22548-2 - Nontraumatic orthopedic conditions of shoulder: genetic and molecular aspects, AP.JP

Abstract

Rotator cuff tear is among the most common and debilitating conditions of the shoulder. Although this disease presents a genetic component, the etiology of these diseases are still unknown. It has been proposed that extracellular matrix alterations may be initiated in tendon cells and may lead to cell proliferation, migration, apoptosis and morphogenesis. An altered balance between extracellular matrix synthesis and degradation may have a role in tendon degeneration and, then, in rotator cuff tear. The present study is a part of a biggest project which aims to identify polymorphisms of gene involved, mainly, in the structure and extracellular matrix modelling of tendon that are associated with the risk of rotator cuff tear. In this subproject, polymorphism in the genes FN1 and TNC will be evaluated. Moreover, the expression of these genes will be evaluated in tissue samples of rotator cuff with and without lesion. To our knowledge, few studies previously evaluated genetic and transcriptional mechanisms involved in the rotator cuff tear. This study will generate new biological information that will allow the better understanding of etiopathology and physiology of both conditions with possible medicine application.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FIGUEIREDO, EDUARDO A.; LOYOLA, LEONOR CASILLA; BELANGERO, PAULO S.; CAMPOS RIBEIRO-DOS-SANTOS, ANDREA KELY; BATISTA SANTOS, SIDNEY EMANUEL; COHEN, CARINA; WAJNSZTEJN, ANDRE; DE OLIVEIRA, ADRIELLE MARTINS; SMITH, MARILIA C.; POCHINI, ALBERTO DE CASTRO; et al. Rotator Cuff Tear Susceptibility Is Associated With Variants in Genes Involved in Tendon Extracellular Matrix Homeostasis. JOURNAL OF ORTHOPAEDIC RESEARCH, v. 38, n. 1, SI, p. 192-201, JAN 2020. (11/22548-2, 12/14768-5, 13/23332-9, 15/02285-8)

COHEN, CARINA; LEAL, MARIANA F.; LOYOLA, LEONOR C.; SANTOS, SIDNEY E. B.; RIBEIRO-DOS-SANTOS, ANDREA K. C.; BELANGERO, PAULO S.; FIGUEIREDO, EDUARDO A.; WAJNSZTEJN, ANDRE; DE OLIVEIRA, ADRIELLE M.; SMITH, MARILIA C.; et al. Genetic variants involved in extracellular matrix homeostasis play a role in the susceptibility to frozen shoulder: A case-control study. JOURNAL OF ORTHOPAEDIC RESEARCH, v. 37, n. 4, p. 948-956, APR 2019. (11/22548-2, 12/14768-5, 13/23332-9, 15/02285-8)

FIGUEIREDO, EDUARDO A.; LOYOLA, LEONOR CASILLA; BELANGERO, PAULO S.; CAMPOS RIBEIRO-DOS-SANTOS, ANDREA KELY; BATISTA SANTOS, SIDNEY EMANUEL; COHEN, CARINA; WAJNSZTEJN, ANDRE; DE OLIVEIRA, ADRIELLE MARTINS; SMITH, MARILIA C.; POCHINI, ALBERTO DE CASTRO; et al. Rotator Cuff Tear Susceptibility Is Associated With Variants in Genes Involved in Tendon Extracellular Matrix Homeostasis. JOURNAL OF ORTHOPAEDIC RESEARCH, v. 38, n. 1, p. 10-pg., 2020-01-01. (15/02285-8, 11/22548-2, 13/23332-9, 12/14768-5)