Bioinformatics and modelling

• Grant number: 13/24212-7
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: March 01, 2014
• End date: April 10, 2018
• Field of knowledge: Biological Sciences - Biology
• Principal Investigator: Hugo Aguirre Armelin
• Grantee: Vincent Olivier Jean-Marie Noel
• Host Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated research grant: 13/07467-1 - CeTICS - Center of Toxins, Immune-Response and Cell Signaling, AP.CEPID

Abstract

Build computational models of the cell cycle control, mitogen activation and inflammationrelated pathways using differential equations and stochastic models. It is expected that the models fit and predict well the experimental (wet lab) and literature data. The fellowship candidates will have solid knowledge in computer science or probability and statistics and must be eager to learn the molecular biology and biochemistry involved. Phase 1 (years 1-2): Build simple models. Phase 2 (years 3-4): Connect the models. Phase 3 (year 5): Enhance the models.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DIAS, MATHEUS H.; FONSECA, CECILIA S.; ZEIDLER, JULIANNA D.; ALBUQUERQUE, LAYRA L.; DA SILVA, MARCELO S.; CARARO-LOPES, EDUARDO; REIS, MARCELO S.; NOEL, VINCENT; DOS SANTOS, EDMILSON O.; PRIOR, IAN A.; et al. Fibroblast Growth Factor 2 lethally sensitizes cancer cells to stress-targeted therapeutic inhibitors. MOLECULAR ONCOLOGY, v. 13, n. 2, p. 17-pg., 2019-02-01. (16/17945-6, 13/09040-5, 12/20186-9, 13/24212-7)

DIAS, MATHEUS H.; FONSECA, CECILIA S.; ZEIDLER, JULIANNA D.; ALBUQUERQUE, LAYRA L.; DA SILVA, MARCELO S.; CARARO-LOPES, EDUARDO; REIS, MARCELO S.; NOEL, VINCENT; DOS SANTOS, EDMILSON O.; PRIOR, IAN A.; et al. Fibroblast Growth Factor 2 lethally sensitizes cancer cells to stress-targeted therapeutic inhibitors. MOLECULAR ONCOLOGY, v. 13, n. 2, p. 290-306, FEB 2019. (12/20186-9, 13/09040-5, 13/24212-7, 16/17945-6)