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Proton MRS evaluation of inflammatory and drug refractoriness biomarkers in temporal lobe epilepsy.

Grant number: 13/21056-4
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): March 01, 2014
Effective date (End): February 28, 2017
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Fernando Cendes
Grantee:Luciana Ramalho Pimentel da Silva
Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Temporal lobe epilepsy (TLE) is the most frequent type of focal epilepsies in adulthood and is often associated to an underlying lesion. Nearly 70% of TLE patients do not achieve seizure control using currently marked antiepileptic drugs (AED). It has been demonstrated both in human resected epileptic tissue and in animal models that epileptogenesis is a multifactorial process related to precipitant insults such as status epilepticus and also inflammatory events might be involved. Several studies using 1H-MRS as a tool have shown a relationship between trauma, viral infections, inflammatory CNS diseases and metabolic alterations, although such a parallel has not been yet demonstrated in human epilepsy. Moreover, glial and inflammatory alterations are possible mechanisms underlying refractoriness in TLE. Thus, our aim will be investigate a possible relationship between metabolic changes on 1H-MRS, inflammatory cytokines biomarkers and refractoriness in TLE. To address this issue, we propose three groups of study: 1 - patients with TLE who did not achieved satisfactory seizure control with the first AED trial (refractory group); 2 - patients who responded to the first AED trial (responsive group); 3 - control subjects (control group). Written informed consent will be taken from all subjects. After a regular T2 axial acquisition to define the region of interest, multivoxel 1H-MRS will be acquired using a PRESS ("Point Resolved Spectroscopy") sequence. Resonance intensities on MRS will be determined from integration of peak areas between frequency bounds using the software LC-Model. Then, the 1H-MRS metabolic profiles will be compared to each cytokine evaluated in the three referred groups.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
URQUIA-OSORIO, HEBEL; PIMENTEL-SILVA, LUCIANA R.; REZENDE, THIAGO JUNQUEIRA RIBEIRO; ALMENDARES-BONILLA, EIMY; YASUDA, CLARISSA L.; CONCHA, LUIS; CENDES, FERNANDO. Superficial and deep white matter diffusion abnormalities in focal epilepsies. Epilepsia, v. N/A, p. 13-pg., . (16/05985-3, 13/21056-4, 13/07559-3)
PIMENTEL-SILVA, LUCIANA R.; CASSEB, RAPHAEL F.; CORDEIRO, MONICA M.; CAMPOS, BRUNO A. G.; ALVIM, MARINA K. M.; ROGERIO, FABIO; YASUDA, CLARISSA L.; CENDES, FERNANDO. Interactions between in vivo neuronal-glial markers, side of hippocampal sclerosis, and pharmacoresponse in temporal lobe epilepsy. Epilepsia, v. 61, n. 5, . (13/21056-4, 14/15918-6, 13/07559-3)
ZANAO, TAMIRES A.; SEITZ-HOLLAND, JOHANNA; O'DONNELL, LAUREN J.; ZHANG, FAN; RATHI, YOGESH; LOPES, TATILA M.; PIMENTEL-SILVA, LUCIANA RAMALHO; YASSUDA, CLARISSA L.; MAKRIS, NIKOS; SHENTON, MARTHA E.; et al. Exploring the impact of hippocampal sclerosis on white matter tracts memory in individuals with mesial temporal lobe epilepsy. EPILEPSIA OPEN, v. 8, n. 3, p. 12-pg., . (13/21056-4, 16/10433-0, 18/05393-4, 13/07559-3)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SILVA, Luciana Ramalho Pimentel da. Pharmacoresponse, hippocampal sclerosis and inflammation in mesial temporal lobe epilepsy: influence on metabolites measured by proton magnetic resonance spectroscopy. 2018. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas Campinas, SP.

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