Extraction, purification and characterization of polysaccharides from Agave sisalana Perrine species targeting different applications in the field of pharmaceutical sciences

• Grant number: 13/22212-0
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: March 01, 2014
• End date: August 31, 2014
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Principal Investigator: Adalberto Pessoa Junior
• Grantee: José Alexsandro da Silva
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The utilization of natural products in the diverse areas of pharmaceutical sciences have acquired new techniques that view to take advantages of the native flora in the development of products with aggregated value. Agave sisalana (sisa), a semi-xerophytic plant that belongs to the agave genre, is a wide known species in the northeast of Brasil. The application of A. sisalana is exclusively limited to the obtainment of fiber, not having any other nutritional or pharmaceutical function in the biotechnological point of view, mainly in the solid and liquid residue (sisal juice). Some preliminary studies with this residue have indicated a possibility of achieving pharmaceutical excipients, antioxidant agents, hormones and prebiotics. Due to these scientific applications, this project aims to obtain brute polysaccharides and purified inulin from the bole and the solid and liquid residues resulting from the defibriation process of the agave leaf. An ample characterization of the structural and physicochemical point of view of these substances with modern techniques is also proposed as well as the evaluation of its antioxidants and prebiotic activity. Therefore, the result of the studies proposed in this project may take a new direction for the utilization of A. sisalana with the possible patent request and with further application prospects of products obtained from this species in the pharmaceutical area.

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

APOLINARIO, ALEXSANDRA CONCEICAO; DE CARVALHO, ERIKA MARTINS; GOULART DE LIMA DAMASCENO, BOLIVAR PONCIANO; DANTAS DA SILVA, PAULO CESAR; CONVERTI, ATTILIO; PESSOA, JR., ADALBERTO; DA SILVA, JOSE ALEXSANDRO. Extraction, isolation and characterization of inulin from Agave sisalana boles. INDUSTRIAL CROPS AND PRODUCTS, v. 108, p. 355-362, DEC 1 2017. (13/22212-0)

APOLINARIO, ALEXSANDRA CONCEICAO; DO NASCIMENTO, MORGANA LOPES; DE LUNA VIEIRA, JULIANA PATRICIA; MELO, CAMILA DE OLIVEIRA; SANTOS, FELIPE FERNANDES; GOULART DE LIMA DAMASCENO, BOLIVAR PONCIANO; CONVERTI, ATTILIO; PESSOA, ADALBERTO; DA SILVA, JOSE ALEXSANDRO. Physico-chemical quality parameters of herbal products from Agave sisalana. NATURAL PRODUCT RESEARCH, v. 28, n. 22, p. 1992-1999, 2014. (13/22212-0)

LOPES, ANDRE MORENI; SANTOS-EBINUMA, VALERIA DE CARVALHO; APOLINARIO, ALEXSANDRA CONCEICAO; BEZERRA MENDONCA, JR., FRANCISCO JAIME; GOULART DE LIMA DAMASCENO, BOLIVAR PONCIANO; PESSOA, JR., ADALBERTO; DA SILVA, JOSE ALEXSANDRO. 5CN05 partitioning in an aqueous two-phase system: A new approach to the solubilization of hydrophobic drugs. Process Biochemistry, v. 49, n. 9, p. 1555-1561, SEP 2014. (13/22212-0)

GUIMARAES, GEOVANI PEREIRA; DE FREITAS ARAUJO REIS, MYSRAYN YARGO; CASIMIRO DA SILVA, DAYANNE TOMAZ; BEZERRA MENDONCA JUNIOR, FRANCISCO JAIME; CONVERTI, ATTILIO; PESSOA, JR., ADALBERTO; GOULART DE LIMA DAMASCENO, BOLIVAR PONCIANO; DA SILVA, JOSE ALEXSANDRO. Antifungal activity of topical microemulsion containing a thiophene derivative. Brazilian Journal of Microbiology, v. 45, n. 2, p. 545-550, APR-JUN 2014. (13/22212-0)