INVOLVEMENT OF THE AUTONOMIC NERVOUS SYSTEM UPON GLUCOSE CONTROL AND PANCREATIC ISLETS FUNCTION IN MALNOURISHED MICE FED A HIGH-FAT DIET

• Grant number: 13/25847-6
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: April 01, 2014
• End date: July 31, 2017
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Everardo Magalhães Carneiro
• Grantee: Camila Lubaczeuski
• Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 13/07607-8 - OCRC - Obesity and Comorbidities Research Center, AP.CEPID

Abstract

Insulin resistance is a risk factor for the development of type 2 diabetes mellitus (DM2), which is associated with overweight and obesity. In addition, studies show that malnutrition increases the chances of developing chronic diseases such as hypertension, glucose intolerance and DM2. Rats submitted to protein restriction have reduced body weight, increased glucose tolerance and insulin sensitivity, despite insulin deficiency. In these animals, there was an increase in sympathetic nervous system (SNS) activity and decreased parasympathetic nervous system (PNS). Obese animals by high-fat diet had an increase in body weight, fat accumulation, hyperglycemia, hyperinsulinemia, glucose intolerance and insulin resistance, reducing the SNS and increased parasympathetic tone. Rodents subjected to protein malnutrition during gestation and lactation, after receiving normal or high calorie diet, showed an increase in growth and may develop obesity and glucose intolerance. However s the role of the SNA in the installation of obesity in early malnourished animals is unknown. The aim is to evaluate the involvement of the autonomic nervous system, through vagal denervation, on glucose homeostasis, morphology and function of pancreatic islets in early undernourished mice underwent fat diet.

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

LUBACZEUSKI, Camila. Involvement of the parasympathetic nervous system on glycemic control and pancreatic islets function in malnourished mice submitted to the high-fat diet. 2017. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia Campinas, SP.