Obesity is a public health problem. Obese individuals are more prone to developing chronic diseases such as Hypertension, Arteriosclerosis and Diabetes Mellitus type 2 (DM2). High-fatty diet is a robust model for the study of obesity and physical exercise is recommended for the treatment and prevention of this pathology. The acute exercise increase the plasmatic concentrations of interleukin-6 (IL-6) and obese individuals also presented elevated concentrations of this cytokine, however a chronic way. Hyperinsulinemia is also increased in obese animals and the physical exercise reverses this processes. We hypothesized that this response be mediated by modulations of the hepatic insulin clearance and the responsible molecule for the cross-talk between muscle and liver during the exercise be the secretion of IL-6 from muscle. For these propose, we will separate the animals in five groups: control (C), obese (O), obese treated with IL-6 (O+IL6), exercised obese (EO), exercised obese treated with IL-6 inhibitor (EO-IL6). Ten days before submit to acute exercise, will be evaluated the maximums oxygen consume (VO2 máx), glucose tolerance test (GTT), insulin tolerance test (ITT) and insulin clearance. After to acute exercise, we will evaluate the glycemic control with the cited tests, besides biochemistry parameters plasmatic, and gene (Real-Time RT-PCR) and protein expression (Western-Blot).
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