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Characteristics of differentiated lipogenic response in adipose tissue of rats subjected to excessive and prolonged stimulation with glucocorticoids

Grant number: 13/24557-4
Support type:Scholarships in Brazil - Master
Effective date (Start): March 01, 2014
Effective date (End): June 30, 2015
Field of knowledge:Biological Sciences - Physiology
Principal Investigator:Fabio Bessa Lima
Grantee:Patricia Pereira Nunes Traldi
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Several factors are involved in regulating the metabolism of white adipose tissue, including glucocorticoids which are hormones produced by the adrenal cortex. In the excess glucocorticoids for prolonged periods a clinical condition called Cushing's syndrome settles. One characteristic of this syndrome is the redistribution of fat in the central regions of the body, and the mechanisms involved in this process are not well understood. Studies have associated this metabolic alteration with changes in the action of the enzymes 11beta-hydroxysteroid dehydrogenase-1 (11BHSD1) and lipoprotein lipase (LPL) and the mineralocorticoid receptor (MR). It is known that glucocorticoids act on LPL and MR and has its tissue concentration regulated by 11BHSD1. However, as there is a inconsistency in the literature regarding the effects of excess glucocorticoids on the TAB, the aim of this project is to investigate the possible effects of excess of these hormones on lipogenesis in various adipose pads, considering its action on 11BHSD1 and LPL enzymes, and on MR. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
NUNES, PATRICIA PEREIRA; ANDREOTTI, SANDRA; SILVA, FLAVIANE DE FATIMA; LAURATO SERTIE, ROGERIO ANTONIO; CAMINHOTTO, RENNAN DE OLIVEIRA; MEDEIROS KOMINO, AYUMI CRISTINA; REIS, GABRIELA BOLTES; LIMA, FABIO BESSA. Chronic low-dose glucocorticoid treatment increases subcutaneous abdominal fat, but not visceral fat, of male Wistar rats. Life Sciences, v. 190, p. 29-35, DEC 1 2017. Web of Science Citations: 4.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
TRALDI, Patricia Pereira Nunes. Chronic, continuous and invariable body exposure to cortisol increases abdominal subcutaneous adipose tissue.. 2016. Master's Dissertation - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas São Paulo.

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