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Action of the metalloproteinases (MMPs) in the gonadal remodeling during the sex inversion in the juvenile and sequential hermaphroditism in Teleostei fish

Grant number: 14/00868-3
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): May 01, 2014
Effective date (End): September 13, 2016
Field of knowledge:Agronomical Sciences - Fishery Resources and Fishery Engineering - Inland Water Fishery Resources
Principal researcher:Irani Quagio Grassiotto
Grantee:Talita Sarah Mazzoni
Home Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Teleostei exhibit great plasticity in the sexual expression and the condition of hermaphroditism among species of different orders is frequent. During the sex inversion, occurs gonadal tissue degeneration from the first sex. After, occurs substitution, development and maturation of the germinal tissue from the opposite sex. The changes from the germinal epithelium are extensively studied, but significant changes also occur in the interstitial compartment. These are little studied. When they are associated with changes from the epithelium, become the main responsible by the morphological and functional changes of the gonad. These changes in gonadal tissue involve extensive remodeling of the interstitial tissue. The metalloproteinases (MMPs) exercise important modulation on extracellular matrix, therefore, the MMPs can be involved in this process during sexual inversion in Teleostei. Due to lack of information about the action of the MMPs in remodeling gonadal in fish, and knowing the necessity of obtain new mechanisms for manipulation sexual, the present study aims to evaluate the action of MMPs in tissue remodeling and her action in the morphological and physiological changes of the gonads, during sex inversion in two species from Teleostei: Danio rerio and Synbranchus marmoratus, which present juvenile and sequential hermaphroditism, respectively. In addition, the proposal intend to establish a comparative analysis on the role of new interstitial cells - the telocytes - not described for Teleostei yet, during the sexual determination between these two species. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MAZZONI, TALITA SARAH; QUAGIO-GRASSIOTTO, IRANI. Presence of the matrix metalloproteinases during the migration of the primordial germ cells in zebrafish gonadal ridge. Cell and Tissue Research, v. 383, n. 2, p. 707-722, FEB 2021. Web of Science Citations: 1.
MAZZONI, TALITA SARAH; VIADANNA, RENAN RIBEIRO; QUAGIO-GRASSIOTTO, IRANI. Presence, localization and morphology of TELOCYTES in developmental gonads of fishes. Journal of Morphology, v. 280, n. 5, p. 654-665, MAY 2019. Web of Science Citations: 0.
MAZZONI, TALITA SARAH; LO NOSTRO, FABIANA LAURA; ANTONELI, FERNANDA NATALIA; QUAGIO-GRASSIOTTO, IRANI. Action of the Metalloproteinases in Gonadal Remodeling during Sex Reversal in the Sequential Hermaphroditism of the Teleostei Fish Synbranchus marmoratus (Synbranchiformes: Synbranchidae). CELLS, v. 7, n. 5 MAY 2018. Web of Science Citations: 4.

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