Sabbatical project proposal at the professor David H. Sherman research group

• Grant number: 14/05670-7
• Support Opportunities: Scholarships abroad - Research
• Start date: July 25, 2014
• End date: February 24, 2015
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Roberto Gomes de Souza Berlinck
• Grantee: Roberto Gomes de Souza Berlinck
• Host Investigator: David H. Sherman
• Host Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
• Institution abroad: University of Michigan, United States

Abstract

We propose to investigate biosynthetic gene clusters of guanidine alkaloids found in a Brazilian specimen of the sponge Monanchora arbuscula. These alkaloids constitute unique chemical entities, which seem to be polyketide-derived, for which a guanidine-derived amino acid can be envisaged as a starting biosynthetic group, possibly derived from arginine. The biosynthetic origin of marine sponge guanidine alkaloids have not yet been investigated. Considering that such alkaloids have an occurrence as very complex mixtures, the investigation of the biosynthetic gene clusters coding for guanidine alkaloids biosynthesis in marine sponges may constitute a considerable challenge to be achieved. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BERLINCK, ROBERTO G. S.; ROMMINGER, STELAMAR. The chemistry and biology of guanidine natural products. NATURAL PRODUCT REPORTS, v. 33, n. 3, p. 456-490, 2016. (14/05670-7)

NEWMISTER, SEAN A.; ROMMINGER, STELAMAR; SCHMIDT, JENNIFER J.; WILLIAMS, ROBERT M.; SMITH, JANET L.; BERLINCK, ROBERTO G. S.; SHERMAN, DAVID H.. Unveiling sequential late-stage methyltransferase reactions in the meleagrin/oxaline biosynthetic pathway. ORGANIC & BIOMOLECULAR CHEMISTRY, v. 16, n. 35, p. 6450-6459, SEP 21 2018. (13/50228-8, 14/05670-7, 12/50026-3)

NEWMISTER, SEAN A.; GOBER, CLAIRE M.; ROMMINGER, STELAMAR; YU, FENGAN; TRIPATHI, ASHOOTOSH; PARRA, LIZBETH LORENA L.; WILLIAMS, ROBERT M.; BERLINCK, ROBERTO G. S.; JOULLIE, MADELEINE M.; SHERMAN, DAVID H.. OxaD: A Versatile Indolic Nitrone Synthase from the Marine-Derived Fungus Penicillium oxalicum F30. Journal of the American Chemical Society, v. 138, n. 35, p. 11176-11184, SEP 7 2016. (12/50026-3, 14/05670-7, 13/50228-8)