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Relation Between Initiation of Pharyngeal Response and Lateralization of Brain Injury in Stroke

Grant number: 14/03848-3
Support type:Scholarships in Brazil - Master
Effective date (Start): June 01, 2014
Effective date (End): February 29, 2016
Field of knowledge:Health Sciences - Speech Therapy
Principal researcher:Roberta Gonçalves da Silva
Grantee:Thaís Coelho Alves
Home Institution: Faculdade de Filosofia e Ciências (FFC). Universidade Estadual Paulista (UNESP). Campus de Marília. Marília , SP, Brazil


The central nervous system is bilaterally neuromotor control of swallowing and the cerebral cortex activates the oral and pharyngeal phases. Although the main findings of oropharyngeal swallowing and location of the lesion in stroke have been related in some studies, are still necessary investigations involving the cortical lesion and changes in the swallowing. The aim of this research is to relate the initiation of pharyngeal response with the consistency of food and lateralization of brain injury in post-stroke individual diagnosed with oropharyngeal dysphagia. This study will be analyzed approximately 150 videofluoroscopic swallowing examinations of individuals post ischemic, acute or chronic stroke with neurological diagnosis confirmed by medical, clinical and neuroimaging examinations. Will be part of this database exams of three dysphagia reference centers in Brazil. They will be divided into two groups, according to the lateralization of the cortical lesion, with group 1 (G1) will have 75 individuals with left cortical lesion, and group 2 (G2) of 75 subjects with right cortical lesion. The examinations of G1 and G2 will be analyzed considering the consistency of liquid, thickened liquid and paste. To check the initiation of pharyngeal response, the exams will be scanned and subsequently analyzed using custom computer software and two judges trained in the procedure. The initiation of pharyngeal response to be considered should follow the statistical average and correlation analysis between the judges. The results will be statistically analyzed through application of association and / or correlation between G1 and G2, depending on the consistency tested, and the pharyngeal response time.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ALVES, THAIS COELHO; COLA, PAULA CRISTINA; JORGE, ADRIANA GOMES; GATTO, ANA RITA; DA SILVA, ROBERTA GONSALVES. Relationship between pharyngeal response time and lateralized brain lesion in stroke. Topics in Stroke Rehabilitation, v. 26, n. 6 JUN 2019. Web of Science Citations: 0.
THAÍS COELHO ALVES; RARISSA RÚBIA DALLAQUA DOS SANTOS; PAULA CRISTINA COLA; ADRIANA GOMES JORGE; ANA RITA GATTO; ROBERTA GONÇALVES DA SILVA. Tempo de trânsito oral e lateralidade da lesão cerebral no acidente vascular encefálico. Audiol., Commun. Res., v. 22, p. -, 2017.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
ALVES, Thaís Coelho. Relação entre início da resposta faríngea e lateralização da lesão cerebral no acidente vascular encefálico. 2016. 89 f. Master's Dissertation - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Filosofia e Ciências..

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