Effect of supplementation with omega-3 fatty acids, with or without practicing regular exercise,in insulin resistance and inflammation in mice subjected to a high fat diet.

• Grant number: 14/06281-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: June 01, 2014
• End date: December 31, 2014
• Field of knowledge: Biological Sciences - Physiology - General Physiology
• Principal Investigator: Sandro Massao Hirabara
• Grantee: Érika Fernandes de Jesus
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Obesity is a major public health problem in both developed countries and in developing countries or poor. In Brazil about 40 % of the population is overweight and obesity is higher in females than in males . Obesity is an etiologic factor in chronic inflammation and consequently the organ dysfunction . Fatty acids have long chain carboxylic acids and , in general, all contain an even number of carbon atoms. The AG family w -3 can be obtained through the diet or produced by the body from linoleic acid and alpha - linolenic acid . The intake of oleic and linoleic fatty acids may increase the release of TNF- a , and the proinflammatory effects accompanying the rapid uptake and metabolism in tissues. In addition, oral supplementation with either GA w -3 fish oil in healthy individuals decreases the production of IL- 1, IL- 2 and IL- 6 and TNF- a in monocytes isolated pro-inflammatory cytokines. Aerobic exercise of mild to moderate intensity has been recommended as a therapy to prevent and treat cardiovascular and related metabolic diseases such as type 2 diabetes mellitus and obesity . These exercises cause several beneficial effects . This project aims to investigate whether supplementation of n-3 FA associated with moderate aerobic exercise can prevent or reduce the deleterious effects of high fat diet in C57BL / 6 mice .