Application of green chemistry strategies for the preparation of tenofovir disoproxil fumarate

• Grant number: 13/16972-1
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: June 01, 2014
• End date: May 31, 2017
• Field of knowledge: Health Sciences - Pharmacy
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: João Luis Callegari Lopes
• Grantee: Rafael Augusto Soldi
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Inhibitors of HIV-1 protease are designed to, generally, act specifically on this enzyme class, characterized by its high affinity and high complementarity to the catalytic site of the protein, intrinsically competing with the natural substrates. The goal of antiretroviral therapy is therefore to slow the progression of immunodeficiency and restore, as much as possible, immunity, increasing the length and quality of life of people living with HIV. Considering the validity and costs of these inhibitors of HIV-1 protease for the Unified Health System (SUS), the project aims to contribute to the production of these drugs in the country and also to study synthetic routes using the "green chemistry" to lessen the environmental impact of production. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

NISHIMURA, RODOLFO H. V.; MURIE, VALTER E.; SOLDI, RAFAEL A.; LOPES, JOAO L. C.; CLOSOSKI, GIULIANO C.. Zinc, Lithium and Magnesium Carbenoids: Chemical Properties and Relevant Applications in Organic Synthesis. Journal of the Brazilian Chemical Society, v. 26, n. 11, p. 2175-2188, NOV 2015. (14/20302-4, 13/16972-1)