| Grant number: | 14/10828-9 |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate |
| Start date: | August 01, 2014 |
| End date: | July 31, 2015 |
| Field of knowledge: | Biological Sciences - Immunology - Cellular Immunology |
| Principal Investigator: | Niels Olsen Saraiva Câmara |
| Grantee: | Cristhiane Favero de Aguiar |
| Supervisor: | Mitchell Kronenberg |
| Host Institution: | Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
| Institution abroad: | La Jolla Institute for Allergy and Immunology (LIAI), United States |
| Associated to the scholarship: | 12/16794-3 - Influence of gut microbiota on NKT cells profile in an experimental model of colitis, BP.DR |
Abstract NKT cells constitute a distinct population of lymphocytes characterized by their reactivity to glycolipids presented by CD1d. Although they are found at a relatively low frequency in most sites, because of their clonal specificity and rapid cytokine production, they have been reported to influence many types of immune responses. NKT cells can be found in several organs and tissues, including the intestine, with low frequencies in intraepithelial lymphocytes (IEL) and a slightly higher prevalence in lamina propria lymphocytes (LPL). The role of NKT cells in intestinal homeostasis and inflammation is still controversial and additional studies are needed to better understand the function of these cells and their relation to the pathogenesis of intestinal diseases. Some recent technologies provide powerful insights into cell biology. These include RNAseq, which yields a more quantitative and detailed picture of global gene expression than microarrays, and ChIP-Seq, which analyzes epigenetic modifications and determines if proteins, such as transcription factors, bind to specific regions on chromatin in vivo. Therefore, our aim is to provide a detailed description at the molecular and cellular level of the function of NKT cells in the intestine, under different conditions, including colitis and in germ free mice. (AU) | |
| News published in Agência FAPESP Newsletter about the scholarship: | |
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