Exploring the ACDC concept on hydrogenation and Friedel-Crafts reactions using indolizines obtained from Morita-Baylis-Hillman adducts

• Grant number: 14/02062-6
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• Start date: January 12, 2015
• End date: January 11, 2016
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Fernando Antonio Santos Coelho
• Grantee: José Tiago Menezes Correia
• Supervisor: Benjamin List
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Institution abroad: Max Planck Society, Mulheim, Germany
• Associated to the scholarship: 12/21809-0 - Organocatalysed synthesis of indolizidinic and quinolizidinic N-heterocycles from Morita-Baylis-Hillman adducts, BP.DR

Abstract

The project consists on a methodological study of two transformations involving Indolizines obtained from Morita-Baylis-Hillman adducts. They are: an asymmetric transfer hydrogenation reaction and an asymmetric Friedel-Crafts alkylation , both catalyzed by chiral phosphoric acids derived from BINOL. The Indolizines are interesting building blocks, since they can be converted to compounds endowed with biological activity and to indolizidinic alkaloids. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MENEZES CORREIA, JOSE TIAGO; LIST, BENJAMIN; COELHO, FERNANDO. Catalytic Asymmetric Conjugate Addition of Indolizines to alpha,beta-Unsaturated Ketones. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v. 56, n. 27, p. 7967-7970, JUN 26 2017. (13/10449-5, 14/02062-6, 13/07600-3)