Catalytic Asymmetric Conjugate Addition of Indoliz... - BV FAPESP
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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Catalytic Asymmetric Conjugate Addition of Indolizines to alpha,beta-Unsaturated Ketones

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Author(s):
Menezes Correia, Jose Tiago ; List, Benjamin ; Coelho, Fernando
Total Authors: 3
Document type: Journal article
Source: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION; v. 56, n. 27, p. 7967-7970, JUN 26 2017.
Web of Science Citations: 34
Abstract

A catalytic enantioselective conjugate addition of indolizines to enones is described. The chiral phosphoric acid (S)-TRIP activates alpha,beta-unsaturated ketones, thereby promoting an enantioface-differentiating attack by indolizines. Using this reaction, several alkylated indolizines were synthesized in good yields and with enantiomeric ratios of up to 98:2. (AU)

FAPESP's process: 13/10449-5 - Morita-Baylis-Hillman adducts as efficient building blocks for the synthesis of molecules of biological interest
Grantee:Fernando Antonio Santos Coelho
Support Opportunities: Regular Research Grants
FAPESP's process: 14/02062-6 - Exploring the ACDC concept on hydrogenation and Friedel-Crafts reactions using indolizines obtained from Morita-Baylis-Hillman adducts
Grantee:José Tiago Menezes Correia
Support Opportunities: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery
Grantee:Glaucius Oliva
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC